SKI proto-oncogene
GO Process (37)
GO Function (9)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.

Nomura T, Tanikawa J, Akimaru H, Kanei-Ishii C, Ichikawa-Iwata E, Khan MM, Ito H, Ishii S

The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic activation. Here we report that TIF1beta directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation. In ... [more]

J. Biol. Chem. Apr. 16, 2004; 279(16);16715-26 [Pubmed: 14761981]


  • Low Throughput

Curated By

  • BioGRID