PREY

SKI

SGS, SKV
SKI proto-oncogene
GO Process (37)
GO Function (9)
GO Component (9)

Gene Ontology Biological Process

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.

Nomura T, Tanikawa J, Akimaru H, Kanei-Ishii C, Ichikawa-Iwata E, Khan MM, Ito H, Ishii S

The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic activation. Here we report that TIF1beta directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation. In ... [more]

J. Biol. Chem. Apr. 16, 2004; 279(16);16715-26 [Pubmed: 14761981]

Throughput

  • Low Throughput

Curated By

  • BioGRID