MYB
Gene Ontology Biological Process
- blood coagulation [TAS]
- chromatin remodeling [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription, DNA-templated [IMP]
- positive regulation of T-helper cell differentiation [IMP]
- positive regulation of histone H3-K4 methylation [IMP]
- positive regulation of histone H3-K9 methylation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IMP, NAS]
- regulation of transcription, DNA-templated [NAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
SKI
Gene Ontology Biological Process
- BMP signaling pathway [TAS]
- SMAD protein signal transduction [IDA]
- anterior/posterior axis specification [ISS]
- bone morphogenesis [ISS]
- camera-type eye development [ISS]
- camera-type eye morphogenesis [ISS]
- cell motility [NAS]
- cell proliferation [NAS]
- embryonic limb morphogenesis [ISS]
- face morphogenesis [ISS]
- gene expression [TAS]
- lens morphogenesis in camera-type eye [ISS]
- myelination in peripheral nervous system [ISS]
- myotube differentiation [IDA]
- negative regulation of BMP signaling pathway [IDA, IMP]
- negative regulation of Schwann cell proliferation [IGI]
- negative regulation of activin receptor signaling pathway [IDA]
- negative regulation of cell proliferation [IDA]
- negative regulation of fibroblast proliferation [ISS]
- negative regulation of osteoblast differentiation [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- negative regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- neural tube closure [ISS]
- nose morphogenesis [ISS]
- olfactory bulb development [ISS]
- palate development [ISS]
- positive regulation of DNA binding [IDA]
- positive regulation of Wnt signaling pathway [NAS]
- positive regulation of transcription from RNA polymerase II promoter [ISS]
- protein homotrimerization [IDA]
- regulation of apoptotic process [IBA]
- retina development in camera-type eye [ISS]
- skeletal muscle fiber development [ISS]
- somatic stem cell maintenance [ISS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [NAS, TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Oncogenic activation of c-Myb correlates with a loss of negative regulation by TIF1beta and Ski.
The c-myb proto-oncogene product (c-Myb) regulates proliferation of hematopoietic cells by inducing the transcription of a group of target genes. Removal or mutations of the negative regulatory domain (NRD) in the C-terminal half of c-Myb leads to increased transactivating capacity and oncogenic activation. Here we report that TIF1beta directly binds to the NRD and negatively regulates the c-Myb-dependent trans-activation. In ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| MYB SKI | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - | |
| SKI MYB | Reconstituted Complex Reconstituted Complex An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator. | Low | - | BioGRID | - |
Curated By
- BioGRID