Reconstituted Complex

An interaction is detected between purified proteins in vitro.


The Drosophila esc and E(z) proteins are direct partners in polycomb group-mediated repression.

Jones CA, Ng J, Peterson AJ, Morgan K, Simon J, Jones RS

The extra sex combs (esc) and Enhancer of zeste [E(z)] proteins are members of the Drosophila Polycomb group (Pc-G) of transcriptional repressors. Here we present evidence for direct physical interaction between the esc and E(z) proteins using yeast two-hybrid and in vitro binding assays. In addition, coimmunoprecipitation from embryo extracts demonstrates association of esc and E(z) in vivo. We have ... [more]

Mol. Cell. Biol. May. 01, 1998; 18(5);2825-34 [Pubmed: 9566901]


  • Low Throughput

Curated By

  • BioGRID