BAIT
KMT2A
ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, hCG_1732268
lysine (K)-specific methyltransferase 2A
GO Process (14)
GO Function (11)
GO Component (5)
Gene Ontology Biological Process
- circadian regulation of gene expression [ISS]
- embryonic hemopoiesis [TAS]
- histone H3-K4 methylation [IDA, IMP]
- histone H3-K4 trimethylation [IDA]
- histone H4-K16 acetylation [IMP]
- positive regulation of cellular response to drug [IMP]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription, DNA-templated [IMP]
- positive regulation of transporter activity [IMP]
- protein complex assembly [IDA]
- regulation of histone H3-K14 acetylation [ISS]
- regulation of histone H3-K9 acetylation [ISS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
- AT DNA binding [NAS]
- core promoter sequence-specific DNA binding [ISS]
- histone methyltransferase activity (H3-K4 specific) [IDA, IMP]
- identical protein binding [IPI]
- lysine-acetylated histone binding [IDA]
- protein binding [IPI]
- protein homodimerization activity [IDA]
- sequence-specific DNA binding transcription factor activity [NAS]
- transcription regulatory region DNA binding [IDA]
- unmethylated CpG binding [IDA]
- zinc ion binding [IDA]
Gene Ontology Cellular Component
Homo sapiens
PREY
MTM1
CNM, MTMX, XLMTM
myotubularin 1
GO Process (10)
GO Function (6)
GO Component (7)
Gene Ontology Biological Process
- endosome to lysosome transport [IDA]
- intermediate filament organization [IMP]
- mitochondrion distribution [IMP]
- mitochondrion morphogenesis [IDA]
- phosphatidylinositol biosynthetic process [TAS]
- phosphatidylinositol dephosphorylation [IDA]
- phospholipid metabolic process [TAS]
- protein dephosphorylation [IDA]
- regulation of vacuole organization [IDA]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Association of SET domain and myotubularin-related proteins modulates growth control.
Several proteins that contribute to epigenetic mechanisms of gene regulation contain a characteristic motif of unknown function called the SET (Suvar3-9, Enhancer-of-zeste, Trithorax) domain. We have demonstrated that SET domains mediate highly conserved interactions with a specific family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). These include myotubularin, the gene of which is mutated in a subset of ... [more]
Nat. Genet. Apr. 01, 1998; 18(4);331-7 [Pubmed: 9537414]
Throughput
- Low Throughput
Curated By
- BioGRID