BAIT

KMT2A

ALL-1, CXXC7, HRX, HTRX1, MLL, MLL/GAS7, MLL1, MLL1A, TET1-MLL, TRX1, WDSTS, hCG_1732268
lysine (K)-specific methyltransferase 2A
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Association of SET domain and myotubularin-related proteins modulates growth control.

Cui X, De Vivo I, Slany R, Miyamoto A, Firestein R, Cleary ML

Several proteins that contribute to epigenetic mechanisms of gene regulation contain a characteristic motif of unknown function called the SET (Suvar3-9, Enhancer-of-zeste, Trithorax) domain. We have demonstrated that SET domains mediate highly conserved interactions with a specific family of proteins that display similarity with dual-specificity phosphatases (dsPTPases). These include myotubularin, the gene of which is mutated in a subset of ... [more]

Nat. Genet. Apr. 01, 1998; 18(4);331-7 [Pubmed: 9537414]

Throughput

  • Low Throughput

Curated By

  • BioGRID