BAIT

YET3

YDL072C
Protein of unknown function; YET3 null mutant decreases the level of secreted invertase; homolog of human BAP31 protein; protein abundance increases in response to DNA replication stress
GO Process (0)
GO Function (0)
GO Component (2)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

INO1

APR1, inositol-3-phosphate synthase INO1, L000000867, YJL153C
Inositol-3-phosphate synthase; involved in synthesis of inositol phosphates and inositol-containing phospholipids; transcription is coregulated with other phospholipid biosynthetic genes by Ino2p and Ino4p, which bind the UASINO DNA element
GO Process (1)
GO Function (1)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Yet1p-Yet3p Interacts with Scs2p-Opi1p to Regulate ER-localization of the Opi1p Repressor.

Wilson JD, Thompson SL, Barlowe C

Lipid sensing mechanisms at the endoplasmic reticulum (ER) coordinate an array of biosynthetic pathways. A major phospholipid regulatory circuit in yeast is controlled by Scs2p, an ER membrane protein that binds the transcriptional repressor protein Opi1p. Cells grown in the absence of inositol sequester Scs2p-Opi1p at the ER and derepress target genes including INO1. We recently reported that Yet1p and ... [more]

Unknown Mar. 03, 2011; 0(0); [Pubmed: 21372176]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: auxotrophy (APO:0000097)
  • phenotype: viability (APO:0000111)

Additional Notes

  • overexpression rescues the growth defects seen under inositol starvation conditions

Curated By

  • BioGRID