BAIT
NFKBIA
AI462015, Nfkbi
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
GO Process (22)
GO Function (8)
GO Component (5)
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [IMP]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
Mus musculus
PREY
FBXW11
2310065A07Rik, AA536858, BTRC2, BTRCP2, Fbxw1b, HOS, RP23-94F11.1
F-box and WD-40 domain protein 11
GO Process (11)
GO Function (3)
GO Component (5)
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- negative regulation of NF-kappaB import into nucleus [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of circadian rhythm [IMP]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein dephosphorylation [IDA]
- protein destabilization [ISO]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [ISO]
Gene Ontology Molecular Function
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB.
NF-kappaB transcription factor is activated upon ubiquitination and subsequent proteolysis of its inhibitor IkappaB. The phosphorylation-dependent ubiquitination is mediated by SCF E3 ubiquitin ligase. In this study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS/betaTrCP2). mHOS efficiently binds Skp1 protein (a 'core' component of SCF ubiquitin ligase), and phosphorylated IkappaB(alpha). We found that mHOS associates ... [more]
Oncogene Feb. 28, 2002; 21(10);1501-9 [Pubmed: 11896578]
Throughput
- Low Throughput
Curated By
- BioGRID