AI462015, Nfkbi
nuclear factor of kappa light polypeptide gene enhancer in B cells inhibitor, alpha
GO Process (22)
GO Function (8)
GO Component (5)

Gene Ontology Cellular Component

Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB.

Bhatia N, Herter JR, Slaga TJ, Fuchs SY, Spiegelman VS

NF-kappaB transcription factor is activated upon ubiquitination and subsequent proteolysis of its inhibitor IkappaB. The phosphorylation-dependent ubiquitination is mediated by SCF E3 ubiquitin ligase. In this study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS/betaTrCP2). mHOS efficiently binds Skp1 protein (a 'core' component of SCF ubiquitin ligase), and phosphorylated IkappaB(alpha). We found that mHOS associates ... [more]

Oncogene Feb. 28, 2002; 21(10);1501-9 [Pubmed: 11896578]


  • Low Throughput

Curated By

  • BioGRID