NFKBIA
Gene Ontology Biological Process
- cytoplasmic sequestering of NF-kappaB [ISO]
- cytoplasmic sequestering of transcription factor [ISO]
- lipopolysaccharide-mediated signaling pathway [IDA]
- negative regulation of NF-kappaB transcription factor activity [ISO]
- negative regulation of Notch signaling pathway [IMP]
- negative regulation of lipid storage [ISO]
- negative regulation of macrophage derived foam cell differentiation [ISO]
- negative regulation of myeloid cell differentiation [IMP]
- nucleotide-binding oligomerization domain containing 1 signaling pathway [IDA]
- nucleotide-binding oligomerization domain containing 2 signaling pathway [IDA]
- positive regulation of cellular protein metabolic process [ISO]
- positive regulation of cholesterol efflux [ISO]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- protein import into nucleus, translocation [IDA]
- regulation of cell proliferation [IDA]
- regulation of gene expression [IMP]
- response to exogenous dsRNA [IDA]
- response to lipopolysaccharide [IDA]
- response to muramyl dipeptide [IDA]
- response to muscle stretch [IDA]
- toll-like receptor 4 signaling pathway [IDA]
Gene Ontology Molecular Function
FBXW11
Gene Ontology Biological Process
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process [IMP, ISO]
- negative regulation of NF-kappaB import into nucleus [IMP]
- negative regulation of transcription, DNA-templated [ISO]
- positive regulation of circadian rhythm [IMP]
- positive regulation of proteolysis [ISO]
- positive regulation of transcription, DNA-templated [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein dephosphorylation [IDA]
- protein destabilization [ISO]
- protein polyubiquitination [IDA, ISO]
- protein ubiquitination [ISO]
Gene Ontology Molecular Function
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Mouse homologue of HOS (mHOS) is overexpressed in skin tumors and implicated in constitutive activation of NF-kappaB.
NF-kappaB transcription factor is activated upon ubiquitination and subsequent proteolysis of its inhibitor IkappaB. The phosphorylation-dependent ubiquitination is mediated by SCF E3 ubiquitin ligase. In this study, we identified a novel murine F-box/WD40 repeat-containing protein, mHOS (a homologue of HOS/betaTrCP2). mHOS efficiently binds Skp1 protein (a 'core' component of SCF ubiquitin ligase), and phosphorylated IkappaB(alpha). We found that mHOS associates ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID