Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

Kamura T, Sato S, Haque D, Liu L, Kaelin WG, Conaway RC, Conaway JW

The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-inducible genes. Elongin B is a ubiquitin-like protein, and Elongin C is a ... [more]

Genes Dev. Dec. 15, 1998; 12(24);3872-81 [Pubmed: 9869640]

Throughput

  • Low Throughput

Curated By

  • BioGRID