ankyrin repeat and SOCS box-containing 2
Mus musculus


2610043E24Rik, 2610301I15Rik, AA407206, AI987979, AW049146
transcription elongation factor B (SIII), polypeptide 1
GO Process (0)
GO Function (2)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Mus musculus

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.

Kamura T, Sato S, Haque D, Liu L, Kaelin WG, Conaway RC, Conaway JW

The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-inducible genes. Elongin B is a ubiquitin-like protein, and Elongin C is a ... [more]

Genes Dev. Dec. 15, 1998; 12(24);3872-81 [Pubmed: 9869640]


  • Low Throughput

Curated By

  • BioGRID