SOCS3
Gene Ontology Biological Process
- JAK-STAT cascade [ISO]
- branching involved in labyrinthine layer morphogenesis [IMP]
- cytokine-mediated signaling pathway [IBA]
- intracellular signal transduction [ISO]
- negative regulation of JAK-STAT cascade [IBA]
- negative regulation of inflammatory response [IGI]
- negative regulation of insulin receptor signaling pathway [IDA]
- negative regulation of protein kinase activity [IBA]
- negative regulation of signal transduction [IGI]
- placenta blood vessel development [IMP]
- positive regulation of cell differentiation [IDA, IGI]
- regulation of cell differentiation [IGI, IMP]
- regulation of protein phosphorylation [IDA]
- signal transduction [ISO]
- spongiotrophoblast differentiation [IGI, IMP]
- trophoblast giant cell differentiation [IGI, IMP]
Gene Ontology Molecular Function
TCEB2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
The Elongin BC complex interacts with the conserved SOCS-box motif present in members of the SOCS, ras, WD-40 repeat, and ankyrin repeat families.
The Elongin BC complex was identified initially as a positive regulator of RNA polymerase II (Pol II) elongation factor Elongin A and subsequently as a component of the multiprotein von Hippel-Lindau (VHL) tumor suppressor complex, in which it participates in both tumor suppression and negative regulation of hypoxia-inducible genes. Elongin B is a ubiquitin-like protein, and Elongin C is a ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SOCS3 TCEB2 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
SOCS3 TCEB2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID