SCNN1A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- apical plasma membrane [ISO]
- ciliary membrane [ISO]
- cortical actin cytoskeleton [ISO]
- cytosol [IDA]
- external side of plasma membrane [IDA]
- extracellular vesicular exosome [ISO]
- integral component of membrane [IDA]
- integral component of plasma membrane [ISO]
- membrane [IDA]
- motile cilium [ISO]
- sodium channel complex [IGI, ISO]
NEDD4L
Gene Ontology Biological Process
- negative regulation of potassium ion transmembrane transport [ISO]
- negative regulation of potassium ion transmembrane transporter activity [ISO]
- negative regulation of protein localization to cell surface [ISO]
- negative regulation of sodium ion transmembrane transport [ISO]
- negative regulation of sodium ion transmembrane transporter activity [ISO]
- negative regulation of sodium ion transport [IDA, IMP, ISO]
- negative regulation of systemic arterial blood pressure [IMP]
- positive regulation of cation channel activity [IGI]
- positive regulation of caveolin-mediated endocytosis [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of sodium ion transport [IGI]
- proteasome-mediated ubiquitin-dependent protein catabolic process [ISO]
- protein K48-linked ubiquitination [ISO]
- protein monoubiquitination [ISO]
- protein ubiquitination [IDA, ISO]
- protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IBA, ISO]
- regulation of ion transmembrane transport [ISO]
- regulation of membrane depolarization [ISO]
- regulation of membrane potential [ISO]
- regulation of membrane repolarization [ISO]
- regulation of potassium ion transmembrane transporter activity [ISO]
- regulation of tight junction assembly [IDA]
- response to metal ion [ISO]
- response to salt stress [IMP]
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway [IDA, IGI]
- ventricular cardiac muscle cell action potential [ISO]
Gene Ontology Molecular Function- ion channel binding [ISO]
- potassium channel inhibitor activity [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [IDA, ISO]
- sodium channel regulator activity [ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IBA, ISO]
- ion channel binding [ISO]
- potassium channel inhibitor activity [ISO]
- potassium channel regulator activity [ISO]
- protein binding [IPI]
- sodium channel inhibitor activity [IDA, ISO]
- sodium channel regulator activity [ISO]
- ubiquitin protein ligase activity [IDA]
- ubiquitin-protein transferase activity [IBA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Phosphorylation of Nedd4-2 by Sgk1 regulates epithelial Na(+) channel cell surface expression.
The epithelial Na(+) channel (ENaC) plays an essential role in the regulation of whole body Na(+) balance and blood pressure. The cell surface expression of this channel, a complex of three subunits (alpha, beta and gamma ENaC), has been shown to be regulated by hormones such as aldosterone and vasopressin and by intracellular signaling, including ubiquitylation and/or phosphorylation. However, the ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| SCNN1A NEDD4L | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
| NEDD4L SCNN1A | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | 728449 | |
| SCNN1A NEDD4L | Far Western Far Western An interaction is detected between a protein immobilized on a membrane and a purified protein probe. | Low | - | BioGRID | - |
Curated By
- BioGRID