BAIT

NEURL1

Xneur, neurl, neurl-A
neuralized E3 ubiquitin protein ligase 1
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis
PREY

UBC

ubiquitin C
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

Deblandre GA, Lai EC, Kintner C

Notch signaling in Drosophila requires a RING finger (RF) protein encoded by neuralized. Here we show that the Xenopus homolog of neuralized (Xneur) is expressed where Notch signaling controls cell fate choices in early embryos. Overexpressing XNeur or putative dominant-negative forms in embryos inhibits Notch signaling. As expected for a RF protein, we show that XNeur fulfills the biochemical requirements ... [more]

Dev. Cell Dec. 01, 2001; 1(6);795-806 [Pubmed: 11740941]

Throughput

  • Low Throughput

Curated By

  • BioGRID