Publication

Xenopus neuralized is a ubiquitin ligase that interacts with XDelta1 and regulates Notch signaling.

Deblandre GA, Lai EC, Kintner C

Notch signaling in Drosophila requires a RING finger (RF) protein encoded by neuralized. Here we show that the Xenopus homolog of neuralized (Xneur) is expressed where Notch signaling controls cell fate choices in early embryos. Overexpressing XNeur or putative dominant-negative forms in embryos inhibits Notch signaling. As expected for a RF protein, we show that XNeur fulfills the biochemical requirements ... [more]

Throughput

• Low Throughput

Curated By

• BioGRID