UBR1
Gene Ontology Biological Process
- cellular response to hyperoxia [IMP]
- negative regulation of SREBP signaling pathway by positive regulation of transcription factor catabolic process in response to increased oxygen levels [IDA]
- negative regulation of transcription by transcription factor catabolism [IMP]
- proteasome localization [IMP]
- proteasome-mediated ubiquitin-dependent protein catabolic process [IMP]
- protein ubiquitination [IMP]
- regulation of filamentous growth [IMP]
Gene Ontology Molecular Function
PAP1
Gene Ontology Biological Process
- cellular response to caffeine [IMP]
- cellular response to hydrogen peroxide [IMP]
- cellular response to oxidative stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to heat stress [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to increased salt [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to menadione [IMP]
- positive regulation of transcription from RNA polymerase II promoter in response to oxidative stress [IMP]
- regulation of transcription from RNA polymerase II promoter [IMP]
- transcription from RNA polymerase II promoter [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- RNA polymerase II core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Fission yeast Ubr1 ubiquitin ligase influences the oxidative stress response via degradation of active Pap1 bZIP transcription factor in the nucleus.
Cells adapt to oxidative stress by transcriptional activation of genes encoding antioxidants and proteins of other protective roles. A bZIP transcription factor, Pap1, plays a critical role in this process and overexpression of Pap1 confers resistance to various oxidants and drugs in fission yeast. Pap1 temporarily enters the nucleus upon oxidative stress but returns to the cytoplasm once cells adapt ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: vegetative growth (APO:0000106)
Additional Notes
- Deletion of PAP1 rescues the growth defect of an ubr1 caf1 double mutant. (ubr1 caf1 pap1 triple mutant)
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
UBR1 PAP1 | Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene. | Low | - | BioGRID | 519147 |
Curated By
- BioGRID