BAIT
FANCG
FAG, XRCC9
Fanconi anemia, complementation group G
GO Process (3)
GO Function (2)
GO Component (6)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ERCC4
ERCC11, FANCQ, RAD1, XPF
excision repair cross-complementation group 4
GO Process (15)
GO Function (8)
GO Component (6)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [IBA, IDA]
- DNA repair [IMP, TAS]
- double-strand break repair via homologous recombination [IMP]
- negative regulation of telomere maintenance [IMP]
- nucleotide-excision repair [IDA, IMP, TAS]
- nucleotide-excision repair involved in interstrand cross-link repair [IBA]
- nucleotide-excision repair, DNA damage removal [TAS]
- nucleotide-excision repair, DNA incision [IDA]
- nucleotide-excision repair, DNA incision, 3'-to lesion [IMP]
- nucleotide-excision repair, DNA incision, 5'-to lesion [IMP]
- resolution of meiotic recombination intermediates [IBA]
- response to UV [IMP]
- telomere maintenance [IMP]
- telomere maintenance via telomere shortening [IMP]
- transcription-coupled nucleotide-excision repair [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Two-hybrid
Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.
Publication
The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1.
There is evidence that Fanconi anemia (FA) proteins play an important role in the repair of DNA interstrand cross-links (ICLs), but the precise mechanism by which this occurs is not clear. One of the critical steps in the ICL repair process involves unhooking of the cross-link from DNA by incisions on one strand on either side of the ICL and ... [more]
Biochemistry Jul. 06, 2010; 49(26);5560-9 [Pubmed: 20518486]
Throughput
- Low Throughput
Curated By
- BioGRID