BAIT

FANCG

FAG, XRCC9
Fanconi anemia, complementation group G
GO Process (3)
GO Function (2)
GO Component (6)
Homo sapiens
PREY

ERCC4

ERCC11, FANCQ, RAD1, XPF
excision repair cross-complementation group 4
Homo sapiens

Two-hybrid

Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation.

Publication

The Fanconi anemia protein, FANCG, binds to the ERCC1-XPF endonuclease via its tetratricopeptide repeats and the central domain of ERCC1.

Wang C, Lambert MW

There is evidence that Fanconi anemia (FA) proteins play an important role in the repair of DNA interstrand cross-links (ICLs), but the precise mechanism by which this occurs is not clear. One of the critical steps in the ICL repair process involves unhooking of the cross-link from DNA by incisions on one strand on either side of the ICL and ... [more]

Biochemistry Jul. 06, 2010; 49(26);5560-9 [Pubmed: 20518486]

Throughput

  • Low Throughput

Curated By

  • BioGRID