BAIT
VPS-26
CELE_T20D3.7
Protein VPS-26
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Caenorhabditis elegans
PREY
SNX-6
CELE_Y59A8B.22
Protein SNX-6
GO Process (6)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- determination of adult lifespan [IMP]
- execution phase of apoptosis [IMP]
- intracellular protein transport [IBA]
- phagolysosome assembly involved in apoptotic cell clearance [IMP]
- phagosome maturation involved in apoptotic cell clearance [IMP]
- phagosome-lysosome fusion involved in apoptotic cell clearance [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Caenorhabditis elegans
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.
The cell surface receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Here, we found that the C. elegans intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1. Retromer was recruited to the surfaces of phagosomes containing cell corpses, and its loss of function caused ... [more]
Science Mar. 05, 2010; 327(5970);1261-4 [Pubmed: 20133524]
Throughput
- Low Throughput
Curated By
- BioGRID