Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Retromer is required for apoptotic cell clearance by phagocytic receptor recycling.

Chen D, Xiao H, Zhang K, Wang B, Gao Z, Jian Y, Qi X, Sun J, Miao L, Yang C

The cell surface receptor CED-1 mediates apoptotic cell recognition by phagocytic cells, enabling cell corpse clearance in Caenorhabditis elegans. Here, we found that the C. elegans intracellular protein sorting complex, retromer, was required for cell corpse clearance by mediating the recycling of CED-1. Retromer was recruited to the surfaces of phagosomes containing cell corpses, and its loss of function caused ... [more]

Science Mar. 05, 2010; 327(5970);1261-4 [Pubmed: 20133524]


  • Low Throughput

Curated By

  • BioGRID