Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.

Walters KB, Green JM, Surfus JC, Yoo SK, Huttenlocher A

CXCR4 is a G protein-coupled chemokine receptor that has been implicated in the pathogenesis of primary immunodeficiency disorders and cancer. Autosomal dominant gain-of-function truncations of CXCR4 are associated with warts, hypo-gammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a primary immunodeficiency disorder characterized by neutropenia and recurrent infections. Recent progress has implicated CXCR4-SDF1 (stromal cell-derived factor 1) signaling in regulating neutrophil homeostasis, ... [more]

Blood Oct. 14, 2010; 116(15);2803-11 [Pubmed: 20592249]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: neutrophil (ZFA:0009327) [mislocalised (PATO:0000628)]

Curated By

  • BioGRID