BAIT
CXCR4B
CXCR4, cb403, zgc:109863, CH1073-406F3.1
chemokine (C-X-C motif), receptor 4b
GO Process (19)
GO Function (1)
GO Component (1)
Gene Ontology Biological Process
- G-protein coupled receptor signaling pathway [IMP]
- ameboidal-type cell migration [IMP]
- axon guidance [IGI, IMP]
- cell migration [IMP]
- fin regeneration [IMP]
- forebrain development [IMP]
- germ cell development [IMP]
- germ cell migration [IMP]
- induction of positive chemotaxis [IMP]
- negative regulation of neutrophil chemotaxis [IMP]
- neuron migration [IMP]
- organ morphogenesis [IMP]
- positive chemotaxis [IMP]
- posterior lateral line neuromast primordium migration [IGI, IMP]
- regulation of axon extension [IDA, IMP]
- response to lipopolysaccharide [IMP]
- retinal ganglion cell axon guidance [IGI]
- tissue regeneration [IEP]
- trigeminal sensory nucleus development [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Danio rerio
PREY
CXCL12A
SDF-1, cxcl12, sdf-1a, sdf1a, wu:fa55e10, wu:fc16h12, wu:fj84c02
chemokine (C-X-C motif) ligand 12a (stromal cell-derived factor 1)
GO Process (24)
GO Function (1)
GO Component (0)
Gene Ontology Biological Process
- axon guidance [IGI, IMP]
- cell migration involved in gastrulation [IGI, IMP]
- cell morphogenesis [IGI]
- chemotaxis [IGI, IMP]
- fin regeneration [IDA, IMP]
- forebrain development [IMP]
- germ cell migration [IMP]
- induction of positive chemotaxis [IMP]
- lymphangiogenesis [IMP]
- lymphoid lineage cell migration into thymus [IGI]
- myofibril assembly [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of hematopoietic stem cell migration [IGI]
- negative regulation of neutrophil chemotaxis [IGI]
- neuron migration [IGI, IMP]
- organ morphogenesis [IMP]
- positive chemotaxis [IMP]
- positive regulation of axon extension involved in axon guidance [IDA]
- positive regulation of cell migration [IMP]
- posterior lateral line neuromast primordium migration [IGI, IMP]
- regulation of axon extension [IMP]
- retinal ganglion cell axon guidance [IDA, IGI]
- striated muscle cell development [IMP]
- trigeminal sensory nucleus development [IGI]
Gene Ontology Molecular Function
Danio rerio
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Live imaging of neutrophil motility in a zebrafish model of WHIM syndrome.
CXCR4 is a G protein-coupled chemokine receptor that has been implicated in the pathogenesis of primary immunodeficiency disorders and cancer. Autosomal dominant gain-of-function truncations of CXCR4 are associated with warts, hypo-gammaglobulinemia, infections, and myelokathexis (WHIM) syndrome, a primary immunodeficiency disorder characterized by neutropenia and recurrent infections. Recent progress has implicated CXCR4-SDF1 (stromal cell-derived factor 1) signaling in regulating neutrophil homeostasis, ... [more]
Blood Oct. 14, 2010; 116(15);2803-11 [Pubmed: 20592249]
Throughput
- Low Throughput
Ontology Terms
- phenotype: neutrophil (ZFA:0009327) [mislocalised (PATO:0000628)]
Curated By
- BioGRID