DID1, RNS4, VPL5, VPS32, ESCRT-III subunit protein SNF7, L000001950, YLR025W
One of four subunits of the ESCRT-III complex; involved in the sorting of transmembrane proteins into the multivesicular body (MVB) pathway; recruited from the cytoplasm to endosomal membranes; ESCRT-III stands for endosomal sorting complex required for transport III
GO Process (4)
GO Function (1)
GO Component (2)
Saccharomyces cerevisiae (S288c)


Sorting nexin; involved in the retrieval of late-Golgi SNAREs from the post-Golgi endosome to the trans-Golgi network; interacts with Snx4p
GO Process (1)
GO Function (2)
GO Component (1)

Gene Ontology Biological Process

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.


ESCRT-II coordinates the assembly of ESCRT-III filaments for cargo sorting and multivesicular body vesicle formation.

Teis D, Saksena S, Judson BL, Emr SD

The sequential action of five distinct endosomal-sorting complex required for transport (ESCRT) complexes is required for the lysosomal downregulation of cell surface receptors through the multivesicular body (MVB) pathway. On endosomes, the assembly of ESCRT-III is a highly ordered process. We show that the length of ESCRT-III (Snf7) oligomers controls the size of MVB vesicles and addresses how ESCRT-II regulates ... [more]

EMBO J. Mar. 03, 2010; 29(5);871-83 [Pubmed: 20134403]


  • Low Throughput

Ontology Terms

  • phenotype: viability (APO:0000111)
  • phenotype: resistance to chemicals (APO:0000087)

Additional Notes

  • double mutant shows decreased sensitivity to cavanine

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Phenotypic Enhancement
Phenotypic Enhancement

A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.


Curated By

  • BioGRID