MCB1, SUN1, proteasome regulatory particle base subunit RPN10, L000003108, YHR200W
Non-ATPase base subunit of the 19S RP of the 26S proteasome; N-terminus plays a role in maintaining the structural integrity of the regulatory particle (RP); binds selectively to polyubiquitin chains; homolog of the mammalian S5a protein
GO Process (1)
GO Function (2)
GO Component (2)
Saccharomyces cerevisiae (S288c)


DBF8, SSM5, L000000489, YIR011C
Protein required for localizing proteasomes to the nucleus; involved in cotranslational protein degradation; mediates interaction between nuclear import factor Srp1p and the proteasome; Sts1p and Srp1p couple proteasomes to nascent polypeptides emerging from the ribosome for cotranslational degradation; involved in ubiquitin-mediated protein degradation
GO Process (3)
GO Function (0)
GO Component (1)
Saccharomyces cerevisiae (S288c)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.


Sts1 plays a key role in targeting proteasomes to the nucleus.

Chen L, Romero L, Chuang SM, Tournier V, Joshi KK, Lee JA, Kovvali G, Madura K

The evidence that nuclear proteins can be degraded by cytosolic proteasomes has received considerable experimental support. However, the presence of proteasome subunits in the nucleus also suggests that protein degradation could occur within this organelle. We determined that Sts1 can target proteasomes to the nucleus and facilitate the degradation of a nuclear protein. Specific sts1 mutants showed reduced nuclear proteasomes ... [more]

J. Biol. Chem. Jan. 28, 2011; 286(4);3104-18 [Pubmed: 21075847]


  • Low Throughput

Ontology Terms

  • phenotype: protein/peptide distribution (APO:0000209)

Additional Notes

  • Overexpression of Sts1 can suppress the proteasome localization defect of rad23/rpn10 double mutants
  • genetic complex

Curated By

  • BioGRID