CG12812, Dmel\CG12812, FAL, Dmel_CG12812
CG12812 gene product from transcript CG12812-RB
GO Process (2)
GO Function (1)
GO Component (0)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Drosophila melanogaster


CG17269, CG31192, CG31194, Dmel\CG17269, FAD, dmFANCD2, Dmel_CG17269
CG17269 gene product from transcript CG17269-RA
GO Process (3)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Drosophila melanogaster

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


The structure of the catalytic subunit FANCL of the Fanconi anemia core complex.

Cole AR, Lewis LP, Walden H

The Fanconi anemia (FA) pathway is activated in response to DNA damage, leading to monoubiquitination of the substrates FANCI and FANCD2 by the FA core complex. Here we report the crystal structure of FANCL, the catalytic subunit of the FA core complex, at 3.2 A. The structure reveals an architecture fundamentally different from previous sequence-based predictions. The molecule is composed ... [more]

Nat. Struct. Mol. Biol. Mar. 01, 2010; 17(3);294-8 [Pubmed: 20154706]


  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Affinity Capture-Western
Affinity Capture-Western

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.


Curated By

  • BioGRID