Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.


Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex.

Bonfils S, Rozalen AE, Smith GR, Moreno S, Martin-Castellanos C

A physical connection between each pair of homologous chromosomes is crucial for reductional chromosome segregation during the first meiotic division and therefore for successful meiosis. Connection is provided by recombination (crossing over) initiated by programmed DNA double-strand breaks (DSBs). Although the topoisomerase-like protein Spo11 makes DSBs and is evolutionarily conserved, how Spo11 (Rec12 in fission yeast) is regulated to form ... [more]

J. Cell. Sci. Apr. 15, 2011; 124(0);1328-38 [Pubmed: 21429938]


  • Low Throughput

Ontology Terms

  • phenotype: spore germination (APO:0000042)

Curated By

  • BioGRID