BAIT
MRE11
rad32, SPAC13C5.07
Mre11 nuclease
GO Process (10)
GO Function (6)
GO Component (2)
Gene Ontology Biological Process
- DNA catabolic process, endonucleolytic [TAS]
- DNA double-strand break processing [IGI, IMP]
- cellular protein localization [IMP]
- double-strand break repair [IMP]
- double-strand break repair via nonhomologous end joining [IMP]
- intra-S DNA damage checkpoint [IMP]
- meiotic DNA double-strand break formation [TAS]
- meiotic gene conversion [IDA]
- mitotic DNA damage checkpoint [IMP]
- reciprocal meiotic recombination [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Schizosaccharomyces pombe (972h)
PREY
REC24
mug6, SPAC1952.15c
meiotic recombination protein Rec24
GO Process (1)
GO Function (0)
GO Component (2)
Schizosaccharomyces pombe (972h)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
Functional interactions of Rec24, the fission yeast ortholog of mouse Mei4, with the meiotic recombination-initiation complex.
A physical connection between each pair of homologous chromosomes is crucial for reductional chromosome segregation during the first meiotic division and therefore for successful meiosis. Connection is provided by recombination (crossing over) initiated by programmed DNA double-strand breaks (DSBs). Although the topoisomerase-like protein Spo11 makes DSBs and is evolutionarily conserved, how Spo11 (Rec12 in fission yeast) is regulated to form ... [more]
J. Cell. Sci. Apr. 15, 2011; 124(0);1328-38 [Pubmed: 21429938]
Throughput
- Low Throughput
Ontology Terms
- phenotype: spore germination (APO:0000042)
Curated By
- BioGRID