inner centromere protein, shugoshin, Sgo1
Schizosaccharomyces pombe (972h)


mitotic spindle checkpoint protein Mad2
Schizosaccharomyces pombe (972h)

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.


Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I.

Hirose Y, Suzuki R, Ohba T, Hinohara Y, Matsuhara H, Yoshida M, Itabashi Y, Murakami H, Yamamoto A

The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment) and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is ... [more]

PLoS Genet. Mar. 01, 2011; 7(3);e1001329 [Pubmed: 21423721]


  • Low Throughput

Ontology Terms

  • phenotype: chromosome segregation (APO:0000208)

Additional Notes

  • deletion of mad2 decreased equational sister centromere separation in both a rec12 single mutant and the rec12/sgo1 double mutant but did not completely abolish it
  • genetic complex

Curated By

  • BioGRID