SIR2L1, RP11-57G10.3
sirtuin 1
GO Process (87)
GO Function (19)
GO Component (14)

Gene Ontology Biological Process

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Transcriptional repression by the basic helix-loop-helix protein Dec2: multiple mechanisms through E-box elements.

Fujimoto K, Hamaguchi H, Hashiba T, Nakamura T, Kawamoto T, Sato F, Noshiro M, Bhawal UK, Suardita K, Kato Y

Dec2, a member of the basic helix-loop-helix (bHLH) superfamily, has been shown to function as a transcriptional repressor and is implicated in cell proliferation and differentiation. In addition, Dec2 transcripts exhibit a striking circadian oscillation in the suprachiasmatic nucleus. To identify the molecular mechanisms by which Dec2 regulates gene expression, we carried out structure-function analyses. Gel retardation and luciferase assays ... [more]

Int. J. Mol. Med. Jun. 01, 2007; 19(6);925-32 [Pubmed: 17487425]


  • Low Throughput

Curated By

  • BioGRID