BAIT

KDM3A

JHDM2A, JHMD2A, JMJD1, JMJD1A, TSGA
lysine (K)-specific demethylase 3A
Homo sapiens
PREY

MYOCD

MYCD
myocardin
GO Process (19)
GO Function (5)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The histone demethylase, Jmjd1a, interacts with the myocardin factors to regulate SMC differentiation marker gene expression.

Lockman K, Taylor JM, Mack CP

We and others have previously shown that the myocardin transcription factors play critical roles in the regulation of smooth muscle cell (SMC) differentiation marker gene expression. In a yeast 2-hybrid screen for proteins that interact with myocardin-related transcription factor-A (MRTF-A), we identified the histone 3 lysine 9 (H3K9)-specific demethylase, Jmjd1a. GST pull-down assays demonstrated that Jmjd1a bound all 3 myocardin ... [more]

Circ. Res. Dec. 07, 2007; 101(12);e115-23 [Pubmed: 17991879]

Throughput

  • Low Throughput

Curated By

  • BioGRID