SIN3A
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- histone deacetylation [IBA]
- negative regulation of circadian rhythm [ISS]
- negative regulation of histone H3-K27 acetylation [IMP]
- negative regulation of protein localization to nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription regulatory region DNA binding [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of chromatin silencing [IMP]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein deacetylation [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Sin3 complex [IDA, NAS]
- cytoplasm [IDA]
- intercellular bridge [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, ISS]
SFPQ
Gene Ontology Biological Process
- RNA splicing [TAS]
- alternative mRNA splicing, via spliceosome [IMP]
- histone H3 deacetylation [ISS]
- mRNA processing [TAS]
- negative regulation of circadian rhythm [ISS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI, IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of oxidative stress-induced intrinsic apoptotic signaling pathway [IDA]
- regulation of circadian rhythm [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Transcriptional activity of androgen receptor is modulated by two RNA splicing factors, PSF and p54nrb.
Nuclear receptors regulate gene activation or repression through dynamic interactions with coregulators. The interactions between nuclear receptors and RNA splicing factors link gene transcription initiation with pre-mRNA splicing, providing a coordinated control of the products of gene transcription. Here we report that two RNA splicing factors, PTB-associated splicing factor (PSF) and p54nrb, synergistically form protein complexes with the androgen receptor ... [more]
Throughput
- Low Throughput
Additional Notes
- ChIP
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SFPQ SIN3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
SFPQ SIN3A | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID