MYOCD
Gene Ontology Biological Process
- cardiac muscle cell differentiation [ISS]
- cardiocyte differentiation [NAS]
- negative regulation of beta-amyloid clearance [IMP]
- negative regulation of cell proliferation [IDA]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- negative regulation of skeletal muscle cell differentiation [IDA]
- positive regulation of cardiac muscle cell differentiation [IDA]
- positive regulation of cardiac vascular smooth muscle cell differentiation [ISS]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of smooth muscle cell differentiation [IDA]
- positive regulation of smooth muscle contraction [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in myocardial precursor cell differentiation [IDA]
- positive regulation of transcription from RNA polymerase II promoter involved in smooth muscle cell differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- regulation of histone acetylation [ISS]
- regulation of smooth muscle cell differentiation [TAS]
- response to hypoxia [IEP]
- smooth muscle cell differentiation [IMP]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- RNA polymerase II transcription factor binding transcription factor activity [ISS]
- core promoter sequence-specific DNA binding [IDA]
- protein binding [IPI]
- transcription factor binding [IPI]
MYOD1
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- histone H3 acetylation [ISS]
- histone H4 acetylation [ISS]
- muscle cell differentiation [TAS]
- muscle cell fate commitment [ISS]
- muscle organ development [TAS]
- myotube cell development [IDA]
- positive regulation of muscle cell differentiation [IDA, TAS]
- positive regulation of myoblast fusion [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA, ISS]
- protein phosphorylation [TAS]
- regulation of RNA splicing [IDA]
- regulation of transcription from RNA polymerase II promoter [TAS]
- skeletal muscle tissue development [TAS]
- transcription from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- E-box binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- transcription coactivator activity [TAS]
- E-box binding [ISS]
- RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity [TAS]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- chromatin DNA binding [ISS]
- core promoter binding [ISS]
- nuclear hormone receptor binding [IPI]
- protein binding [IPI]
- protein heterodimerization activity [ISS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Reconstituted Complex
An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.
Publication
Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation.
Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation. Myocardin (Myocd) is a serum ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID