BAIT

MYOCD

MYCD
myocardin
GO Process (19)
GO Function (5)
GO Component (1)

Gene Ontology Cellular Component

Homo sapiens
PREY

MYOD1

MYF3, MYOD, PUM, bHLHc1
myogenic differentiation 1
Homo sapiens

Reconstituted Complex

An interaction is inferred between proteins in vitro. This can include proteins in recombinant form or proteins isolated directly from cells with recombinant or purified bait. For example, GST pull-down assays where a GST-tagged protein is first isolated and then used to fish interactors from cell lysates are considered reconstituted complexes (e.g. PUBMED: 14657240, Fig. 4A or PUBMED: 14761940, Fig. 5). This can also include gel-shifts, surface plasmon resonance, isothermal titration calorimetry (ITC) and bio-layer interferometry (BLI) experiments. The bait-hit directionality may not be clear for 2 interacting proteins. In these cases the directionality is up to the discretion of the curator.

Publication

Myocardin is a bifunctional switch for smooth versus skeletal muscle differentiation.

Long X, Creemers EE, Wang DZ, Olson EN, Miano JM

Skeletal and smooth muscle can mutually transdifferentiate, but little molecular insight exists as to how each muscle program may be subverted to the other. The myogenic basic helix-loop-helix transcription factors MyoD and myogenin (Myog) direct the development of skeletal muscle and are thought to be dominant over the program of smooth muscle cell (SMC) differentiation. Myocardin (Myocd) is a serum ... [more]

Proc. Natl. Acad. Sci. U.S.A. Oct. 16, 2007; 104(42);16570-5 [Pubmed: 17940050]

Throughput

  • Low Throughput

Curated By

  • BioGRID