A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Chiasmata Promote Monopolar Attachment of Sister Chromatids and Their Co-Segregation toward the Proper Pole during Meiosis I.

Hirose Y, Suzuki R, Ohba T, Hinohara Y, Matsuhara H, Yoshida M, Itabashi Y, Murakami H, Yamamoto A

The chiasma is a structure that forms between a pair of homologous chromosomes by crossover recombination and physically links the homologous chromosomes during meiosis. Chiasmata are essential for the attachment of the homologous chromosomes to opposite spindle poles (bipolar attachment) and their subsequent segregation to the opposite poles during meiosis I. However, the overall function of chiasmata during meiosis is ... [more]

PLoS Genet. Mar. 01, 2011; 7(3);e1001329 [Pubmed: 21423721]

Throughput

Low Throughput

Ontology Terms

phenotype: chromosome segregation (APO:0000208)

Additional Notes

mad2/rec12 sister centromeres frequently dissociate and fail to move toward the poles, which is only rarely seen in a mad2 single mutant

Related interactions

Interaction	Experimental Evidence Code	Dataset	Throughput	Score	Curated By	Notes
REC12 MAD2	Phenotypic Suppression Phenotypic Suppression A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.	Hirose Y (2011)	Low	-	BioGRID	519663

Curated By

BioGRID

Interaction Summary

MAD2

Gene Ontology Biological Process

Gene Ontology Molecular Function

anaphase-promoting complex binding [IPI]protein binding [IPI]

Gene Ontology Cellular Component

REC12