BAIT
WNT11
Slb/Wnt11, cb748, slb, CH73-223D24.3
wingless-type MMTV integration site family, member 11
GO Process (39)
GO Function (5)
GO Component (3)
Gene Ontology Biological Process
- Kupffer's vesicle development [IGI]
- camera-type eye development [IMP]
- cell migration [IMP]
- cell migration involved in gastrulation [IGI, IMP]
- central nervous system development [IMP]
- convergent extension [IGI]
- convergent extension involved in axis elongation [IGI, IMP]
- convergent extension involved in gastrulation [IGI, IMP]
- embryonic eye morphogenesis [IGI, IMP]
- establishment of mitotic spindle orientation [IMP]
- eye field cell fate commitment involved in camera-type eye formation [IMP]
- gastrulation with mouth forming second [IMP]
- heart development [IGI, IMP]
- heart looping [IGI]
- mediolateral intercalation [IMP]
- mesodermal cell migration [IGI, IMP]
- negative regulation of apoptotic process [ISS]
- negative regulation of canonical Wnt signaling pathway [IGI, ISS]
- negative regulation of cell growth [ISS]
- negative regulation of cell migration [ISS]
- negative regulation of transcription, DNA-templated [ISS]
- neural plate morphogenesis [IMP]
- neuroendocrine cell differentiation [ISS]
- neuron differentiation [IBA]
- non-canonical Wnt signaling pathway [IMP]
- palate development [ISS]
- pancreas development [IMP]
- positive regulation of Ras GTPase activity [ISS]
- positive regulation of cell migration [ISS]
- positive regulation of protein kinase C signaling [ISS]
- positive regulation of protein kinase activity [ISS]
- positive regulation of stress fiber assembly [ISS]
- positive regulation of transcription, DNA-templated [ISS]
- protein localization [IGI]
- protein localization to cell surface [ISS]
- protein phosphorylation [ISS]
- regulation of endocytosis [IMP]
- regulation of protein kinase activity [IMP]
- single organismal cell-cell adhesion [IGI, IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Danio rerio
PREY
DESI2
DeSI-2, cb238, desi1, pppde1, sb:cb238, wu:fi12d12, zgc:100860
desumoylating isopeptidase 2
GO Process (1)
GO Function (0)
GO Component (0)
Gene Ontology Biological Process
Danio rerio
Phenotypic Enhancement
A genetic interaction is inferred when mutation or overexpression of one gene results in enhancement of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Pnas4 is a novel regulator for convergence and extension during vertebrate gastrulation.
Recent studies show that human Pnas4 might be tumor associated, while its function remains unknown. Here, we investigate the developmental function of Pnas4 using zebrafish as a model system. Knocking down Pnas4 causes gastrulation defects with a shorter and broader axis, as well as a posteriorly mis-positioned prechordal plate, due to the defective convergence and extension movement. Conversely, over-expression of ... [more]
FEBS Lett. Jun. 25, 2008; 582(15);2325-32 [Pubmed: 18538138]
Throughput
- Low Throughput
Ontology Terms
- phenotype: post-vent region (ZFA:0001117) [decreased length (PATO:0000574)]
Curated By
- BioGRID