RUNX1
Gene Ontology Biological Process
- hematopoietic stem cell proliferation [TAS]
- hemopoiesis [IDA, TAS]
- myeloid cell differentiation [IDA]
- negative regulation of granulocyte differentiation [IMP]
- peripheral nervous system neuron development [TAS]
- positive regulation of angiogenesis [ISS]
- positive regulation of granulocyte differentiation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IMP]
- positive regulation of transcription, DNA-templated [IDA]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- calcium ion binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IDA]
- DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA, IMP]
- RNA polymerase II transcription regulatory region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA, IMP]
- calcium ion binding [IDA]
- protein binding [IPI]
- protein heterodimerization activity [IDA]
- protein homodimerization activity [IDA]
- regulatory region DNA binding [IDA]
- sequence-specific DNA binding transcription factor activity [IDA]
- transcription factor binding [IDA]
Gene Ontology Cellular Component
SIN3A
Gene Ontology Biological Process
- activation of innate immune response [IMP]
- blood coagulation [TAS]
- cellular lipid metabolic process [TAS]
- histone deacetylation [IBA]
- negative regulation of circadian rhythm [ISS]
- negative regulation of histone H3-K27 acetylation [IMP]
- negative regulation of protein localization to nucleus [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IMP]
- negative regulation of transcription regulatory region DNA binding [IMP]
- negative regulation of transcription, DNA-templated [ISS]
- positive regulation of chromatin silencing [IMP]
- positive regulation of defense response to virus by host [IMP]
- positive regulation of transcription from RNA polymerase II promoter [IMP]
- protein deacetylation [IMP]
- small molecule metabolic process [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Sin3 complex [IDA, NAS]
- cytoplasm [IDA]
- intercellular bridge [IDA]
- nucleoplasm [IDA, TAS]
- nucleus [IDA, ISS]
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The corepressor mSin3A regulates phosphorylation-induced activation, intranuclear location, and stability of AML1.
The AML1 (RUNX1) gene, one of the most frequent targets of translocations associated with human leukemias, encodes a DNA-binding protein that plays pivotal roles in myeloid differentiation through transcriptional regulation of various genes. Previously, we reported that AML1 is phosphorylated on two serine residues with dependence on activation of extracellular signal-regulated kinase, which positively regulates the transcriptional activity of AML1. ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
SIN3A RUNX1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID