Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Surface-scanning mutational analysis of protein arginine methyltransferase 1: roles of specific amino acids in methyltransferase substrate specificity, oligomerization, and coactivator function.

Lee DY, Ianculescu I, Purcell D, Zhang X, Cheng X, Stallcup MR

Protein arginine methyltransferase 1 (PRMT1) is an arginine-specific protein methyltransferase that methylates a number of proteins involved in transcription and other aspects of RNA metabolism. Its role as a transcriptional coactivator for nuclear receptors involves its ability to bind to other coactivators, such as glucocorticoid receptor-interacting protein 1 (GRIP1), as well as its ability to methylate histone H4 and coactivators ... [more]

Mol. Endocrinol. Jun. 01, 2007; 21(6);1381-93 [Pubmed: 17426288]


  • Low Throughput

Curated By

  • BioGRID