BAIT

SAS3

KAT6, L000003280, YBL052C
Histone acetyltransferase catalytic subunit of NuA3 complex; acetylates histone H3, involved in transcriptional silencing; homolog of the mammalian MOZ proto-oncogene; mutant has aneuploidy tolerance; sas3gcn5 double mutation is lethal
Saccharomyces cerevisiae (S288c)
PREY

HHO1

histone H1, L000003354, YPL127C
Histone H1, linker histone with roles in meiosis and sporulation; decreasing levels early in sporulation may promote meiosis, and increasing levels during sporulation facilitate compaction of spore chromatin; binds to promoters and within genes in mature spores; may be recruited by Ume6p to promoter regions, contributing to transcriptional repression outside of meiosis; suppresses DNA repair involving homologous recombination
GO Process (4)
GO Function (1)
GO Component (3)
Saccharomyces cerevisiae (S288c)

Synthetic Rescue

A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.

Publication

Acetylation of Rsc4p by Gcn5p is essential in the absence of histone H3 acetylation.

Choi JK, Grimes DE, Rowe KM, Howe LJ

Rsc4p, a subunit of the RSC chromatin-remodeling complex, is acetylated at lysine 25 by Gcn5p, a well-characterized histone acetyltransferase (HAT). Mutation of lysine 25 does not result in a significant growth defect, and therefore whether this modification is important for the function of the essential RSC complex was unknown. In a search to uncover the molecular basis for the lethality ... [more]

Mol. Cell. Biol. Dec. 01, 2008; 28(23);6967-72 [Pubmed: 18809572]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: inviable (APO:0000112)

Additional Notes

  • Deletion of HHO1 partially rescues an sas3 gcn5 double mutant.

Curated By

  • BioGRID