BAIT
PAXIP1
CAGF29, PACIP1, PAXIP1L, PTIP, TNRC2, CAGF28
PAX interacting (with transcription-activation domain) protein 1
GO Process (9)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IMP]
- histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K36 methylation [ISS]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of histone acetylation [ISS]
- positive regulation of isotype switching [ISS]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of transcription initiation from RNA polymerase II promoter [IMP, ISS]
- response to ionizing radiation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
SMC1A
CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB, RP6-29D12.1
structural maintenance of chromosomes 1A
GO Process (14)
GO Function (5)
GO Component (11)
Gene Ontology Biological Process
- DNA repair [TAS]
- RNA splicing [TAS]
- gene expression [TAS]
- mRNA splicing, via spliceosome [TAS]
- meiotic nuclear division [ISS]
- mitotic cell cycle [TAS]
- mitotic cell cycle checkpoint [IDA]
- mitotic sister chromatid cohesion [TAS]
- mitotic sister chromatid segregation [TAS]
- mitotic spindle organization [TAS]
- negative regulation of DNA endoreduplication [IMP]
- response to radiation [IEP]
- signal transduction in response to DNA damage [IDA]
- sister chromatid cohesion [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
Affinity Capture-MS
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.
Publication
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
The MLL family of histone methyltransferases maintains active chromatin domains by methylating histone H3 on lysine 4 (H3K4). How MLL complexes recognize specific chromatin domains in a temporal and tissue-specific manner remains unclear. We show that the DNA-binding protein PAX2 promotes assembly of an H3K4 methyltransferase complex through the ubiquitously expressed nuclear factor PTIP (pax transcription activation domain interacting protein). ... [more]
Dev. Cell Oct. 01, 2007; 13(4);580-92 [Pubmed: 17925232]
Throughput
- Low Throughput
Curated By
- BioGRID