L000004279, YLR429W
Coronin; cortical actin cytoskeletal component that associates with the Arp2p/Arp3p complex to regulate its activity; plays a role in regulation of actin patch assembly
Saccharomyces cerevisiae (S288c)


ACT4, actin-related protein 3, L000003198, YJR065C
Essential component of the Arp2/3 complex; Arp2/3 is a highly conserved actin nucleation center required for the motility and integrity of actin patches; involved in endocytosis and membrane growth and polarity
GO Process (3)
GO Function (1)
GO Component (2)

Gene Ontology Molecular Function

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)

Reconstituted Complex

An interaction is detected between purified proteins in vitro.


Mechanism of a concentration-dependent switch between activation and inhibition of ARP2/3 complex by coronin.

Liu SL, Needham KM, May JR, Nolen BJ

Arp2/3 complex is a key actin filament nucleator that assembles branched actin networks in response to cellular signals. The activity of Arp2/3 complex is regulated by both activating and inhibitory proteins. Coronins make up a large class of actin binding proteins previously shown to inhibit Arp2/3 complex. While coronins are known to play a role in controlling actin dynamics in ... [more]

Unknown Mar. 21, 2011; 0(0); [Pubmed: 21454476]


  • Low Throughput

Related interactions

InteractionExperimental Evidence CodeDatasetThroughputScoreCurated ByNotes
Affinity Capture-MS
Affinity Capture-MS

An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods.


Curated By

  • BioGRID