CDC42
Gene Ontology Biological Process
- budding cell apical bud growth [IMP]
- budding cell isotropic bud growth [IMP]
- conjugation with cellular fusion [IMP]
- establishment of cell polarity [IMP]
- invasive growth in response to glucose limitation [IMP]
- pheromone-dependent signal transduction involved in conjugation with cellular fusion [IGI, IMP]
- positive regulation of exocytosis [IGI, IMP, IPI]
- positive regulation of pseudohyphal growth [IMP]
- regulation of exit from mitosis [IMP]
- regulation of exocyst localization [IMP]
- regulation of initiation of mating projection growth [IMP]
- regulation of vacuole fusion, non-autophagic [IMP]
- septin ring organization [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
MSB3
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Synthetic Lethality
A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition.
Publication
The GAP activity of Msb3p and Msb4p for the Rab GTPase Sec4p is required for efficient exocytosis and actin organization.
Polarized growth in Saccharomyces cerevisiae is thought to occur by the transport of post-Golgi vesicles along actin cables to the daughter cell, and the subsequent fusion of the vesicles with the plasma membrane. Previously, we have shown that Msb3p and Msb4p genetically interact with Cdc42p and display a GTPase-activating protein (GAP) activity toward a number of Rab GTPases in vitro. ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: inviable (APO:0000112)
Additional Notes
- MSB3/MSB4/CDC42 triple mutants are synthetic lethal
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| CDC42 MSB3 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 154818 | |
| CDC42 MSB3 | Dosage Rescue Dosage Rescue A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene. | Low | - | BioGRID | 520007 | |
| MSB3 CDC42 | Negative Genetic Negative Genetic Mutations/deletions in separate genes, each of which alone causes a minimal phenotype, but when combined in the same cell results in a more severe fitness defect or lethality under a given condition. This term is reserved for high or low throughput studies with scores. | High | -7.9134 | BioGRID | 585192 | |
| CDC42 MSB3 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
| CDC42 MSB3 | Synthetic Growth Defect Synthetic Growth Defect A genetic interaction is inferred when mutations in separate genes, each of which alone causes a minimal phenotype, result in a significant growth defect under a given condition when combined in the same cell. | High | - | BioGRID | 452405 | |
| CDC42 MSB3 | Synthetic Lethality Synthetic Lethality A genetic interaction is inferred when mutations or deletions in separate genes, each of which alone causes a minimal phenotype, result in lethality when combined in the same cell under a given condition. | High | - | BioGRID | 80660 |
Curated By
- BioGRID