PAXIP1
Gene Ontology Biological Process
- DNA damage response, signal transduction by p53 class mediator [IMP]
- histone H3-K4 methylation [IDA]
- positive regulation of histone H3-K36 methylation [ISS]
- positive regulation of histone H3-K4 methylation [ISS]
- positive regulation of histone acetylation [ISS]
- positive regulation of isotype switching [ISS]
- positive regulation of protein ubiquitination [ISS]
- positive regulation of transcription initiation from RNA polymerase II promoter [IMP, ISS]
- response to ionizing radiation [IDA]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
HIST1H3A
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Biochemical Activity (Methylation)
An interaction is inferred from the biochemical effect of one protein upon another, for example, GTP-GDP exchange activity or phosphorylation of a substrate by a kinase. The bait protein executes the activity on the substrate hit protein. A Modification value is recorded for interactions of this type with the possible values Phosphorylation, Ubiquitination, Sumoylation, Dephosphorylation, Methylation, Prenylation, Acetylation, Deubiquitination, Proteolytic Processing, Glucosylation, Nedd(Rub1)ylation, Deacetylation, No Modification, Demethylation.
Publication
The BRCT-domain containing protein PTIP links PAX2 to a histone H3, lysine 4 methyltransferase complex.
The MLL family of histone methyltransferases maintains active chromatin domains by methylating histone H3 on lysine 4 (H3K4). How MLL complexes recognize specific chromatin domains in a temporal and tissue-specific manner remains unclear. We show that the DNA-binding protein PAX2 promotes assembly of an H3K4 methyltransferase complex through the ubiquitously expressed nuclear factor PTIP (pax transcription activation domain interacting protein). ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID