BAIT
RAD23
L000001568, YEL037C
Protein with ubiquitin-like N terminus; subunit of Nuclear Excision Repair Factor 2 (NEF2) with Rad4p that binds damaged DNA; enhances protein deglycosylation activity of Png1p; also involved, with Rad4p, in ubiquitylated protein turnover
GO Process (3)
GO Function (4)
GO Component (3)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Saccharomyces cerevisiae (S288c)
PREY
MIG1
CAT4, SSN1, TDS22, transcription factor MIG1, L000001110, YGL035C
Transcription factor involved in glucose repression; sequence specific DNA binding protein containing two Cys2His2 zinc finger motifs; regulated by the SNF1 kinase and the GLC7 phosphatase; regulates filamentous growth along with Mig2p in response to glucose depletion; activated in stochastic pulses of nuclear localization, shuttling between cytosol and nucleus depending on external glucose levels and its phosphorylation state
GO Process (4)
GO Function (3)
GO Component (3)
Gene Ontology Biological Process
- negative regulation of transcription from RNA polymerase II promoter [IGI, IMP]
- negative regulation of transcription from RNA polymerase II promoter by glucose [IDA, IGI, IMP]
- positive regulation of filamentous growth of a population of unicellular organisms in response to starvation [IGI]
- positive regulation of transcription from RNA polymerase II promoter [IGI, IMP]
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
Synthetic Rescue
A genetic interaction is inferred when mutations or deletions of one gene rescues the lethality or growth defect of a strain mutated or deleted for another gene.
Publication
The Snf1 kinase and proteasome-associated Rad23 regulate UV-responsive gene expression.
The transcriptional response to damaging agents is of fundamental significance for understanding mechanisms responsible for cell survival and genome maintenance. However, how damage signals are transmitted to the transcriptional apparatus is poorly understood. Here we identify two new regulators of the UV response transcriptome: Snf1, a nutrient-sensing kinase, and Rad23, a nucleotide excision repair factor with no previously known function ... [more]
EMBO J. Oct. 07, 2009; 28(19);2919-31 [Pubmed: 19680226]
Throughput
- Low Throughput
Ontology Terms
- vegetative growth (APO:0000106)
Additional Notes
- Deletion of Mig1 rescues the growth defects seen in an Snf1/Rad23 double mutant
- genetic complex
Curated By
- BioGRID