NCOR2
Gene Ontology Biological Process
- Notch signaling pathway [TAS]
- cellular lipid metabolic process [TAS]
- gene expression [TAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IMP, TAS]
- regulation of cellular ketone metabolic process by negative regulation of transcription from RNA polymerase II promoter [IMP]
- small molecule metabolic process [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
- transforming growth factor beta receptor signaling pathway [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
ESR2
Gene Ontology Biological Process
- cell-cell signaling [TAS]
- extracellular negative regulation of signal transduction [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [TAS]
- negative regulation of cell growth [NAS]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- regulation of transcription, DNA-templated [TAS]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
Gene Ontology Molecular Function- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
- DNA binding [TAS]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [TAS]
- estrogen response element binding [IDA]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA, NAS]
- protein binding [IPI]
- receptor antagonist activity [NAS]
- sequence-specific DNA binding transcription factor activity [TAS]
- steroid binding [ISS, TAS]
- steroid hormone receptor activity [TAS]
- transcription coactivator activity [TAS]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Differential recruitment of coregulator proteins steroid receptor coactivator-1 and silencing mediator for retinoid and thyroid receptors to the estrogen receptor-estrogen response element by beta-estradiol and 4-hydroxytamoxifen in human breast cancer.
Estrogen receptor (ER)-alpha and ER-beta function as transcription factors, and both interact with nuclear regulatory proteins to enhance or inhibit transcription. We hypothesized that coregulators are expressed in breast cancer and may be differentially recruited by ERs in the presence of estrogen and tamoxifen. ER-beta was found to be expressed more frequently in node-negative patients (P < 0.05). Expression of ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| ESR2 NCOR2 | Affinity Capture-MS Affinity Capture-MS An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner is identified by mass spectrometric methods. | High | - | BioGRID | - |
Curated By
- BioGRID