BAIT

GIS4

L000004864, YML006C
CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

GIS2

L000004862, YNL255C
Translational activator for mRNAs with internal ribosome entry sites; associates with polysomes and binds to a specific subset of mRNAs; localizes to RNA processing bodies (P bodies) and to stress granules; may have a role in translation regulation under stress conditions; ortholog of human ZNF9/CNBP, a gene involved in myotonic dystrophy type 2
GO Process (1)
GO Function (3)
GO Component (4)
Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.

Balciunas D, Ronne H

Cyclin C and the cyclin C-dependent protein kinase are associated with the RNA polymerase II Mediator complex, which regulates initiation of transcription in response to signals from activators and repressors bound to upstream promoter elements. Disruption of the corresponding genes, SRB11 and SRB10, in budding yeast causes a reduction in expression of the GAL genes, which is particularly pronounced in ... [more]

Mol. Gen. Genet. Dec. 01, 1999; 262(4);589-99 [Pubmed: 10628841]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: utilization of carbon source (APO:0000098)
  • phenotype: vegetative growth (APO:0000106)

Additional Notes

  • Overexpression of Gis2 can rescue growth in an snf1/mig1/gis4 triple mutant
  • genetic complex

Curated By

  • BioGRID