BAIT

GIS4

L000004864, YML006C
CAAX box containing protein of unknown function; proposed to be involved in the RAS/cAMP signaling pathway
GO Process (2)
GO Function (0)
GO Component (1)

Gene Ontology Cellular Component

Saccharomyces cerevisiae (S288c)
PREY

SGE1

NOR1, L000001876, YPR198W
Plasma membrane multidrug transporter; member of the major facilitator superfamily; acts as an extrusion permease; partial multicopy suppressor of gal11 mutations
GO Process (2)
GO Function (1)
GO Component (2)

Gene Ontology Biological Process

Gene Ontology Molecular Function

Saccharomyces cerevisiae (S288c)

Dosage Rescue

A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.

Publication

Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.

Balciunas D, Ronne H

Cyclin C and the cyclin C-dependent protein kinase are associated with the RNA polymerase II Mediator complex, which regulates initiation of transcription in response to signals from activators and repressors bound to upstream promoter elements. Disruption of the corresponding genes, SRB11 and SRB10, in budding yeast causes a reduction in expression of the GAL genes, which is particularly pronounced in ... [more]

Mol. Gen. Genet. Dec. 01, 1999; 262(4);589-99 [Pubmed: 10628841]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: vegetative growth (APO:0000106)
  • phenotype: heat sensitivity (APO:0000147)
  • phenotype: utilization of carbon source (APO:0000098)

Additional Notes

  • Overexpression of SGE1 can partially rescue growth in an snf1/mig1/gis4 triple mutant
  • genetic complex

Curated By

  • BioGRID