BAIT
PDE2
SRA5, 3',5'-cyclic-nucleotide phosphodiesterase PDE2, L000002046, YOR360C
High-affinity cyclic AMP phosphodiesterase; component of the cAMP-dependent protein kinase signaling system, protects the cell from extracellular cAMP, contains readthrough motif surrounding termination codon
GO Process (1)
GO Function (1)
GO Component (2)
Gene Ontology Biological Process
Gene Ontology Molecular Function
Saccharomyces cerevisiae (S288c)
PREY
GIS3
L000004863, YLR094C
Protein of unknown function
GO Process (1)
GO Function (0)
GO Component (2)
Saccharomyces cerevisiae (S288c)
Dosage Rescue
A genetic interaction is inferred when over expression or increased dosage of one gene rescues the lethality or growth defect of a strain that is mutated or deleted for another gene.
Publication
Yeast genes GIS1-4: multicopy suppressors of the Gal- phenotype of snf1 mig1 srb8/10/11 cells.
Cyclin C and the cyclin C-dependent protein kinase are associated with the RNA polymerase II Mediator complex, which regulates initiation of transcription in response to signals from activators and repressors bound to upstream promoter elements. Disruption of the corresponding genes, SRB11 and SRB10, in budding yeast causes a reduction in expression of the GAL genes, which is particularly pronounced in ... [more]
Mol. Gen. Genet. Dec. 01, 1999; 262(4);589-99 [Pubmed: 10628841]
Throughput
- Low Throughput
Ontology Terms
- utilization of carbon source (APO:0000098)
- vegetative growth (APO:0000106)
- heat sensitivity (APO:0000147)
Additional Notes
- Overexpression of Gis3 can rescue growth in an snf1/mig1/pde2 triple mutant
- genetic complex
Curated By
- BioGRID