BAIT
PHB
HEL-215, HEL-S-54e, PHB1
prohibitin
GO Process (15)
GO Function (4)
GO Component (8)
Gene Ontology Biological Process
- cellular response to interleukin-6 [IDA]
- histone deacetylation [IDA]
- negative regulation of androgen receptor signaling pathway [IDA, IMP]
- negative regulation of cell growth [IMP]
- negative regulation of cell proliferation [IMP]
- negative regulation of glucocorticoid receptor signaling pathway [IDA]
- negative regulation of transcription by competitive promoter binding [IDA]
- negative regulation of transcription from RNA polymerase II promoter [IDA]
- negative regulation of transcription, DNA-templated [IDA, IMP]
- osteoblast differentiation [IDA]
- positive regulation of transcription, DNA-templated [IDA]
- progesterone receptor signaling pathway [IDA]
- regulation of apoptotic process [TAS]
- regulation of transcription, DNA-templated [IDA]
- signal transduction [TAS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Homo sapiens
PREY
ESR1
ER, ESR, ESRA, ESTRR, Era, NR3A1, RP1-130E4.1
estrogen receptor 1
GO Process (22)
GO Function (16)
GO Component (6)
Gene Ontology Biological Process
- cellular response to estradiol stimulus [ISS]
- chromatin remodeling [NAS]
- gene expression [TAS]
- intracellular estrogen receptor signaling pathway [NAS]
- intracellular steroid hormone receptor signaling pathway [ISS]
- negative regulation of I-kappaB kinase/NF-kappaB signaling [IDA]
- negative regulation of gene expression [IDA]
- negative regulation of sequence-specific DNA binding transcription factor activity [IDA]
- phospholipase C-activating G-protein coupled receptor signaling pathway [ISS]
- positive regulation of cytosolic calcium ion concentration [ISS]
- positive regulation of nitric oxide biosynthetic process [IDA]
- positive regulation of nitric-oxide synthase activity [IDA]
- positive regulation of phospholipase C activity [ISS]
- positive regulation of retinoic acid receptor signaling pathway [IDA]
- positive regulation of sequence-specific DNA binding transcription factor activity [IDA]
- positive regulation of transcription from RNA polymerase II promoter [IDA]
- regulation of transcription, DNA-templated [NAS]
- response to estradiol [IDA]
- response to estrogen [IDA]
- signal transduction [TAS]
- transcription initiation from RNA polymerase II promoter [TAS]
- transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding [IDA]
- RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription [IDA]
- beta-catenin binding [IPI]
- chromatin binding [IDA]
- core promoter sequence-specific DNA binding [IDA]
- enzyme binding [IPI]
- estrogen receptor activity [NAS]
- estrogen response element binding [IDA]
- estrogen-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IGI]
- identical protein binding [IPI]
- nitric-oxide synthase regulator activity [NAS]
- protein binding [IPI]
- sequence-specific DNA binding transcription factor activity [NAS]
- steroid binding [ISS]
- steroid hormone receptor activity [TAS]
- transcription factor binding [IPI]
Gene Ontology Cellular Component
Homo sapiens
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
A repressive role for prohibitin in estrogen signaling.
Nuclear receptor-mediated gene expression is regulated by corepressors and coactivators. In this study we demonstrate that prohibitin (PHB), a potential tumor suppressor, functions as a potent transcriptional corepressor for estrogen receptor alpha (ERalpha). Overexpression of PHB inhibits ERalpha transcriptional activity, whereas depletion of endogenous PHB increases the expression of ERalpha target genes in MCF-7 breast cancer cells. Chromatin immunoprecipitation experiments ... [more]
Mol. Endocrinol. Feb. 01, 2008; 22(2);344-60 [Pubmed: 17932104]
Throughput
- Low Throughput
Curated By
- BioGRID