ING2
Gene Ontology Biological Process
- chromatin modification [ISS]
- male germ-line stem cell asymmetric division [ISS]
- male meiosis I [ISS]
- negative regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator [TAS]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA]
- regulation of cellular senescence [NAS]
- regulation of response to DNA damage stimulus [NAS]
- regulation of transcription, DNA-templated [IDA]
- seminiferous tubule development [ISS]
- signal transduction [TAS]
- sperm motility [ISS]
- spermatid development [ISS]
- spermatogenesis [ISS]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
COPS2
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
The tumor suppressors p33ING1 and p33ING2 interact with alien in vivo and enhance alien-mediated gene silencing.
The tumor suppressor p33ING1 is involved in DNA repair and cell cycle regulation. Furthermore, p33ING1 is a transcriptional silencer that recognizes the histone mark for trimethylated lysine 4 at histone H3. Interestingly, expression of p33ING1 and p33ING2 is able to induce premature senescence in primary human fibroblasts. The corepressor Alien is involved in gene silencing mediated by selected members of ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
ING2 COPS2 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID