BAIT

ATF4

CREB-2, CREB2, TAXREB67, TXREB
activating transcription factor 4
GO Process (20)
GO Function (7)
GO Component (6)
Homo sapiens
PREY

KAT2B

CAF, P/CAF, PCAF
K(lysine) acetyltransferase 2B
Homo sapiens

Reconstituted Complex

An interaction is detected between purified proteins in vitro.

Publication

The p300/CBP-associated factor (PCAF) is a cofactor of ATF4 for amino acid-regulated transcription of CHOP.

Cherasse Y, Maurin AC, Chaveroux C, Jousse C, Carraro V, Parry L, Deval C, Chambon C, Fafournoux P, Bruhat A

When an essential amino acid is limited, a signaling cascade is triggered that leads to increased translation of the 'master regulator', activating transcription factor 4 (ATF4), and resulting in the induction of specific target genes. Binding of ATF4 to the amino acid response element (AARE) is an essential step in the transcriptional activation of CHOP (a CCAAT/enhancer-binding protein-related gene) by ... [more]

Nucleic Acids Res. Aug. 30, 2007; 35(17);5954-65 [Pubmed: 17726049]

Throughput

  • Low Throughput

Curated By

  • BioGRID