BAIT
APC
AI047805, AU020952, AW124434, CC1, Min, mAPC
adenomatosis polyposis coli
GO Process (59)
GO Function (9)
GO Component (30)
Gene Ontology Biological Process
- T cell differentiation in thymus [IMP]
- Wnt signaling pathway [IDA, IMP]
- anterior/posterior pattern specification [IMP]
- axis specification [IMP]
- axonogenesis [IGI, IMP]
- canonical Wnt signaling pathway [IMP]
- canonical Wnt signaling pathway involved in negative regulation of apoptotic process [IGI]
- canonical Wnt signaling pathway involved in positive regulation of apoptotic process [IGI]
- cell cycle arrest [ISO]
- cell migration [IMP, ISO]
- cellular response to DNA damage stimulus [ISO]
- chromosome organization [IGI, IMP]
- cytoplasmic microtubule organization [IGI]
- dorsal/ventral pattern formation [IMP]
- establishment or maintenance of cell polarity [ISO]
- hair follicle development [IMP]
- kidney development [IMP]
- metaphase/anaphase transition of mitotic cell cycle [IGI, IMP]
- mitotic cytokinesis [IMP, ISO]
- mitotic spindle assembly checkpoint [ISO]
- muscle cell cellular homeostasis [IGI]
- negative regulation of MAPK cascade [IGI, IMP]
- negative regulation of Wnt signaling pathway [IGI, IMP]
- negative regulation of apoptotic process [IMP]
- negative regulation of canonical Wnt signaling pathway [IMP, ISO]
- negative regulation of cell proliferation [IGI, IMP, ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [ISO]
- negative regulation of epithelial cell proliferation [IGI, IMP]
- negative regulation of epithelial cell proliferation involved in prostate gland development [IMP]
- negative regulation of microtubule depolymerization [IMP, ISO]
- negative regulation of odontogenesis [IMP]
- neuron projection development [ISO]
- pattern specification process [IMP]
- positive regulation of apoptotic process [IMP, ISO]
- positive regulation of cell adhesion [IMP]
- positive regulation of cell differentiation [IMP]
- positive regulation of cell division [IMP]
- positive regulation of cell migration [IMP, ISO]
- positive regulation of epithelial cell differentiation [IGI]
- positive regulation of microtubule polymerization [IMP]
- positive regulation of protein catabolic process [IMP, ISO]
- positive regulation of pseudopodium assembly [ISO]
- protein complex assembly [ISO]
- proximal/distal pattern formation [IMP]
- regulation of attachment of spindle microtubules to kinetochore [IMP, ISO]
- regulation of cell cycle [IMP]
- regulation of cell differentiation [IGI]
- regulation of cell migration [IGI, IMP]
- regulation of epithelial cell differentiation [IMP]
- regulation of glutamate metabolic process [ISO]
- regulation of microtubule-based process [ISO]
- regulation of nitrogen compound metabolic process [IMP]
- regulation of osteoblast differentiation [IMP]
- regulation of osteoclast differentiation [IMP]
- retina development in camera-type eye [IMP]
- skin development [IMP]
- somatic stem cell maintenance [IGI, IMP]
- stem cell maintenance [IMP]
- thymus development [IMP]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
- Scrib-APC-beta-catenin complex [IDA]
- axon [IDA]
- axonal growth cone [IDA, ISO]
- beta-catenin destruction complex [ISO]
- cell [IGI]
- cell body fiber [ISO]
- cell cortex [ISO]
- cell projection [IDA]
- cell projection membrane [IDA]
- cell-cell adherens junction [ISO]
- centrosome [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic microtubule [IDA]
- dendrite [ISO]
- growth cone [IDA, ISO]
- kinetochore [ISO]
- lamellipodium [ISO]
- lateral plasma membrane [ISO]
- microtubule [ISO]
- microtubule plus-end [IDA]
- neuron projection [ISO]
- neuron projection terminus [ISO]
- neuronal cell body [ISO]
- nuclear membrane [ISO]
- nucleus [IDA, ISO]
- plasma membrane [ISO]
- protein complex [ISO]
- ruffle membrane [ISO]
- synapse [ISO]
- tight junction [ISO]
Mus musculus
PREY
AXIN1
AI316800, Axin, Fu, Kb, Ki, fused, kinky, knobbly
axin 1
GO Process (53)
GO Function (19)
GO Component (14)
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, IPI, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [IMP]
- axial mesoderm development [IMP]
- axial mesoderm formation [IMP]
- canonical Wnt signaling pathway [IDA, IMP]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IGI]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IDA, ISO]
- dorsal/ventral pattern formation [IMP, ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IMP]
- erythrocyte homeostasis [IMP]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [IMP]
- hemoglobin metabolic process [IMP]
- in utero embryonic development [IGI, IMP]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [IDA, ISO]
- negative regulation of canonical Wnt signaling pathway [IDA]
- negative regulation of fat cell differentiation [IDA]
- negative regulation of protein metabolic process [IDA]
- negative regulation of transcription elongation from RNA polymerase II promoter [IDA]
- neurological system process [IMP]
- nucleocytoplasmic transport [IDA]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [IMP]
- positive regulation of JUN kinase activity [IDA, IMP, ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [IDA]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [ISO]
- positive regulation of protein phosphorylation [IDA, ISO]
- positive regulation of protein ubiquitination [IDA, IGI, IMP]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [IDA, ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [IDA, IGI, IMP]
- positive regulation of ubiquitin-protein transferase activity [IMP, ISO]
- post-anal tail morphogenesis [IMP]
- protein catabolic process [IDA]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [IDA]
- regulation of catenin import into nucleus [IDA]
- regulation of protein phosphorylation [IGI]
- sensory perception of sound [IMP]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [IDA, IPI, ISO]
- R-SMAD binding [IPI]
- SMAD binding [ISO]
- armadillo repeat domain binding [IBA, ISO]
- beta-catenin binding [IMP, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IPI, ISO]
- p53 binding [IPI]
- protein C-terminus binding [IDA, IPI]
- protein binding [IPI]
- protein complex scaffold [IMP, ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [IPI]
- protein kinase binding [IPI, ISO]
- protein self-association [IPI]
- receptor binding [ISO]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [IPI, ISO]
Gene Ontology Cellular Component
- Golgi apparatus [ISO]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IDA]
- cell periphery [ISO]
- cytoplasm [IDA, ISO]
- cytoplasmic membrane-bounded vesicle [IDA]
- cytoplasmic microtubule [IDA]
- cytoplasmic vesicle [ISO]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IBA, ISO]
- protein complex [IDA]
Mus musculus
Reconstituted Complex
An interaction is detected between purified proteins in vitro.
Publication
Mechanism of phosphorylation-dependent binding of APC to beta-catenin and its role in beta-catenin degradation.
The transcriptional coactivator beta-catenin mediates Wnt growth factor signaling. In the absence of a Wnt signal, casein kinase 1 (CK1) and glycogen synthase kinase-3beta (GSK-3beta) phosphorylate cytosolic beta-catenin, thereby flagging it for recognition and destruction by the ubiquitin/proteosome machinery. Phosphorylation occurs in a multiprotein complex that includes the kinases, beta-catenin, axin, and the Adenomatous Polyposis Coli (APC) protein. The role ... [more]
Mol. Cell Aug. 27, 2004; 15(4);511-21 [Pubmed: 15327768]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| AXIN1 APC | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - |
Curated By
- BioGRID