BAIT
RARA
Nr1b1, RAR, RARalpha1, RP23-333D2.3
retinoic acid receptor, alpha
GO Process (61)
GO Function (26)
GO Component (8)
Gene Ontology Biological Process
- Sertoli cell fate commitment [IMP]
- apoptotic cell clearance [ISO]
- bone development [IGI]
- cellular response to estrogen stimulus [ISO]
- cellular response to lipopolysaccharide [IDA]
- cellular response to retinoic acid [ISO]
- chondroblast differentiation [IMP]
- embryonic camera-type eye development [IGI]
- face development [IGI]
- germ cell development [IMP]
- glandular epithelial cell development [IGI]
- growth plate cartilage development [IGI]
- intracellular estrogen receptor signaling pathway [ISO]
- limb development [IGI]
- male gonad development [ISO]
- multicellular organism growth [IGI]
- negative regulation of apoptotic process [IGI]
- negative regulation of cartilage development [IMP]
- negative regulation of cell differentiation [IMP]
- negative regulation of cell proliferation [ISO]
- negative regulation of gene expression [IGI]
- negative regulation of granulocyte differentiation [ISO]
- negative regulation of interferon-gamma production [ISO]
- negative regulation of transcription from RNA polymerase II promoter [IDA, IGI]
- negative regulation of transcription, DNA-templated [IDA, ISO]
- negative regulation of translation [ISO]
- negative regulation of translational initiation [IDA]
- negative regulation of tumor necrosis factor production [ISO]
- neural tube closure [IGI]
- outflow tract septum morphogenesis [IGI]
- positive regulation of ERK1 and ERK2 cascade [ISO]
- positive regulation of T-helper 2 cell differentiation [ISO]
- positive regulation of binding [ISO]
- positive regulation of cell cycle [ISO]
- positive regulation of cell proliferation [IGI, ISO]
- positive regulation of gene expression [IMP]
- positive regulation of interleukin-13 production [ISO]
- positive regulation of interleukin-4 production [ISO]
- positive regulation of interleukin-5 production [ISO]
- positive regulation of neuron differentiation [ISO]
- positive regulation of phosphatidylinositol 3-kinase signaling [ISO]
- positive regulation of protein kinase B signaling [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IDA, IGI, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- protein phosphorylation [ISO]
- regulation of apoptotic process [ISO]
- regulation of granulocyte differentiation [IMP]
- regulation of myelination [ISO]
- regulation of phosphatidylinositol 3-kinase activity [ISO]
- regulation of synaptic plasticity [ISO]
- regulation of transcription, DNA-templated [IDA]
- response to estradiol [ISO]
- response to ethanol [ISO]
- response to retinoic acid [IMP, ISO]
- retinoic acid receptor signaling pathway [IDA, ISO]
- signal transduction [ISO]
- spermatogenesis [IMP]
- trachea cartilage development [IMP]
- transcription from RNA polymerase II promoter [IDA]
- ureteric bud development [IMP]
- ventricular cardiac muscle cell differentiation [IMP]
Gene Ontology Molecular Function- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
- DNA binding [IDA]
- RNA polymerase II regulatory region DNA binding [IDA]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- chromatin DNA binding [ISO]
- drug binding [ISO]
- enzyme binding [ISO]
- histone deacetylase binding [ISO]
- ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity [IDA]
- mRNA 5'-UTR binding [ISO]
- phosphatidylinositol 3-kinase regulator activity [ISO]
- protein binding [IPI]
- protein domain specific binding [ISO]
- protein heterodimerization activity [ISO]
- protein kinase A binding [ISO]
- protein kinase B binding [ISO]
- receptor binding [ISO]
- retinoic acid binding [ISO]
- retinoic acid receptor activity [IDA, ISO]
- retinoic acid-responsive element binding [ISO]
- sequence-specific DNA binding [IDA, IGI]
- sequence-specific DNA binding transcription factor activity [IDA, ISO]
- transcription coactivator activity [ISO]
- transcription corepressor activity [ISO]
- transcription factor binding [IPI, ISO]
- transcription regulatory region DNA binding [IMP]
- translation repressor activity, nucleic acid binding [ISO]
Gene Ontology Cellular Component
Mus musculus
PREY
KAT2B
A930006P13Rik, AI461839, AW536563, Pcaf, p/CAF
K(lysine) acetyltransferase 2B
GO Process (21)
GO Function (14)
GO Component (9)
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cellular response to insulin stimulus [ISO]
- chromatin remodeling [ISO]
- histone H3 acetylation [ISO]
- histone H3-K9 acetylation [IGI]
- histone acetylation [IDA]
- internal peptidyl-lysine acetylation [IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- peptidyl-lysine acetylation [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of histone H3-K14 acetylation [ISO]
- positive regulation of histone H3-K9 acetylation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasodilation [ISO]
- protein acetylation [ISO, TAS]
- regulation of protein ADP-ribosylation [ISO]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Mus musculus
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1.
Orphan nuclear receptor TR2 is a preadipocyte proliferator. Knockdown of TR2 in 3T3-L1 preadipocytes reduced their proliferation efficiency, whereas specific elevation of TR2 in these cells facilitated their proliferation. All-trans retinoic acid (RA) stimulates cellular proliferation in 3T3-L1 preadipocytes by activating TR2 through an IR0-type RA response element, which further activates c-Myc expression. In post-differentiated adipocytes, RA becomes a repressive ... [more]
Nucleic Acids Res. Mar. 29, 2007; 35(7);2269-82 [Pubmed: 17389641]
Throughput
- Low Throughput
Curated By
- BioGRID