GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
NRIP1
Gene Ontology Biological Process
- circadian regulation of gene expression [IMP, ISO]
- lipid storage [IMP]
- negative regulation of transcription from RNA polymerase II promoter [IDA, ISO]
- ovarian follicle rupture [IMP]
- ovulation [IMP]
- positive regulation of transcription from RNA polymerase II promoter [ISO]
- regulation of transcription from RNA polymerase II promoter [IDA]
Gene Ontology Molecular Function- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
- core promoter sequence-specific DNA binding [ISO]
- estrogen receptor binding [ISO]
- glucocorticoid receptor binding [ISO]
- histone deacetylase binding [IPI]
- nuclear hormone receptor binding [ISO]
- protein binding [IPI]
- receptor binding [IPI]
- retinoic acid receptor binding [IPI]
- retinoid X receptor binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription corepressor activity [IDA, ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1.
Orphan nuclear receptor TR2 is a preadipocyte proliferator. Knockdown of TR2 in 3T3-L1 preadipocytes reduced their proliferation efficiency, whereas specific elevation of TR2 in these cells facilitated their proliferation. All-trans retinoic acid (RA) stimulates cellular proliferation in 3T3-L1 preadipocytes by activating TR2 through an IR0-type RA response element, which further activates c-Myc expression. In post-differentiated adipocytes, RA becomes a repressive ... [more]
Throughput
- Low Throughput
Related interactions
| Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
|---|---|---|---|---|---|---|
| GRIP1 NRIP1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID