GRIP1
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
KAT2B
Gene Ontology Biological Process
- N-terminal peptidyl-lysine acetylation [ISO]
- cellular response to insulin stimulus [ISO]
- chromatin remodeling [ISO]
- histone H3 acetylation [ISO]
- histone H3-K9 acetylation [IGI]
- histone acetylation [IDA]
- internal peptidyl-lysine acetylation [IMP, ISO]
- negative regulation of cell proliferation [ISO]
- negative regulation of cyclin-dependent protein serine/threonine kinase activity [IDA]
- peptidyl-lysine acetylation [ISO]
- positive regulation of chromatin binding [ISO]
- positive regulation of gluconeogenesis by positive regulation of transcription from RNA polymerase II promoter [IGI]
- positive regulation of histone H3-K14 acetylation [ISO]
- positive regulation of histone H3-K9 acetylation [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of transcription from RNA polymerase II promoter [IGI, ISO]
- positive regulation of transcription, DNA-templated [IDA]
- positive regulation of vasodilation [ISO]
- protein acetylation [ISO, TAS]
- regulation of protein ADP-ribosylation [ISO]
- regulation of transcription, DNA-templated [TAS]
Gene Ontology Molecular Function- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
- RNA polymerase II regulatory region sequence-specific DNA binding [IDA]
- acetyltransferase activity [ISO]
- chromatin binding [ISO]
- cyclin-dependent protein serine/threonine kinase inhibitor activity [IDA]
- histone acetyltransferase activity [IDA, ISO]
- histone acetyltransferase binding [ISO]
- histone deacetylase binding [ISO]
- lysine N-acetyltransferase activity, acting on acetyl phosphate as donor [IDA, ISO]
- protein binding [IPI]
- protein complex binding [ISO]
- protein kinase binding [IPI]
- transcription coactivator activity [IDA, ISO]
- transcription cofactor activity [ISO]
- transcription factor binding [ISO]
Gene Ontology Cellular Component
Affinity Capture-Western
An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins.
Publication
Orphan nuclear receptor TR2, a mediator of preadipocyte proliferation, is differentially regulated by RA through exchange of coactivator PCAF with corepressor RIP140 on a platform molecule GRIP1.
Orphan nuclear receptor TR2 is a preadipocyte proliferator. Knockdown of TR2 in 3T3-L1 preadipocytes reduced their proliferation efficiency, whereas specific elevation of TR2 in these cells facilitated their proliferation. All-trans retinoic acid (RA) stimulates cellular proliferation in 3T3-L1 preadipocytes by activating TR2 through an IR0-type RA response element, which further activates c-Myc expression. In post-differentiated adipocytes, RA becomes a repressive ... [more]
Throughput
- Low Throughput
Curated By
- BioGRID