DVL1
Gene Ontology Biological Process
- Wnt signaling pathway [ISO, TAS]
- Wnt signaling pathway, planar cell polarity pathway [ISO]
- axon extension [ISO]
- axon guidance [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [IBA, ISO]
- cochlea morphogenesis [ISO]
- collateral sprouting [ISO]
- convergent extension involved in neural plate elongation [ISO]
- convergent extension involved in organogenesis [ISO]
- cytoplasmic microtubule organization [ISO]
- dendrite morphogenesis [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- neural tube development [ISO]
- neuromuscular junction development [ISO]
- neurotransmitter secretion [ISO]
- planar cell polarity pathway involved in neural tube closure [IBA, ISO]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [ISO]
- protein localization to microtubule [ISO]
- protein localization to nucleus [ISO]
- receptor clustering [ISO]
- regulation of neurotransmitter levels [ISO]
- regulation of protein phosphorylation [ISO]
- skeletal muscle acetylcholine-gated channel clustering [ISO]
- social behavior [ISO]
- synapse organization [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
AXIN1
Gene Ontology Biological Process
- Wnt signaling pathway [IDA, ISO]
- Wnt signaling pathway involved in somitogenesis [IBA]
- Wnt-activated signaling pathway involved in forebrain neuron fate commitment [IBA]
- activation of JUN kinase activity [IBA]
- activation of protein kinase activity [ISO]
- adult walking behavior [ISO]
- axial mesoderm development [ISO]
- axial mesoderm formation [IBA, ISO]
- canonical Wnt signaling pathway [ISO, TAS]
- canonical Wnt signaling pathway involved in neural plate anterior/posterior pattern formation [IBA]
- cell death [IBA]
- cellular protein complex assembly [ISO]
- cellular response to organic cyclic compound [IBA]
- cytoplasmic microtubule organization [IBA, ISO]
- determination of left/right symmetry [IBA]
- dorsal/ventral axis specification [IBA, ISO]
- dorsal/ventral pattern formation [ISO]
- embryonic eye morphogenesis [IBA]
- embryonic skeletal joint morphogenesis [IBA, ISO]
- erythrocyte homeostasis [ISO]
- forebrain anterior/posterior pattern specification [IBA]
- genetic imprinting [ISO]
- hemoglobin metabolic process [ISO]
- in utero embryonic development [ISO]
- muscle cell development [IBA]
- negative regulation of Wnt signaling pathway [ISO, TAS]
- negative regulation of canonical Wnt signaling pathway [IBA, ISO]
- negative regulation of fat cell differentiation [IBA, ISO]
- negative regulation of protein metabolic process [ISO]
- negative regulation of transcription elongation from RNA polymerase II promoter [ISO]
- neurological system process [ISO]
- nucleocytoplasmic transport [ISO]
- olfactory placode formation [IBA]
- optic placode formation [IBA]
- positive regulation of GTPase activity [IBA]
- positive regulation of JNK cascade [ISO, ISS]
- positive regulation of JUN kinase activity [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein catabolic process [ISO]
- positive regulation of protein kinase activity [IDA]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of protein ubiquitination [ISO]
- positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process [IDA, ISO]
- positive regulation of transcription, DNA-templated [ISO]
- positive regulation of transforming growth factor beta receptor signaling pathway [ISO]
- positive regulation of ubiquitin-protein transferase activity [ISO]
- post-anal tail morphogenesis [ISO]
- protein catabolic process [ISO]
- protein homooligomerization [IDA, ISO]
- protein polyubiquitination [ISO]
- regulation of catenin import into nucleus [IBA, ISO]
- regulation of protein phosphorylation [ISO]
- sensory perception of sound [ISO]
Gene Ontology Molecular Function- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
- GTPase activator activity [IBA]
- I-SMAD binding [ISO]
- R-SMAD binding [ISO]
- SMAD binding [ISO]
- armadillo repeat domain binding [IDA]
- beta-catenin binding [IDA, IPI, ISO]
- enzyme binding [ISO]
- identical protein binding [IDA, IPI, ISO]
- p53 binding [ISO]
- protein C-terminus binding [ISO]
- protein binding [IPI]
- protein complex scaffold [ISO]
- protein domain specific binding [IPI, ISO]
- protein homodimerization activity [ISO, ISS]
- protein kinase binding [IPI, ISO]
- protein self-association [ISO]
- receptor binding [IPI]
- signal transducer activity [ISO]
- ubiquitin protein ligase binding [ISO]
Gene Ontology Cellular Component
- Golgi apparatus [IDA]
- beta-catenin destruction complex [IDA, ISO]
- cell cortex [IBA, ISO]
- cell periphery [ISO]
- cytoplasm [ISO]
- cytoplasmic membrane-bounded vesicle [IBA, ISO]
- cytoplasmic microtubule [IBA, ISO]
- cytoplasmic vesicle [IDA]
- lateral plasma membrane [ISO]
- nucleus [ISO]
- perinuclear region of cytoplasm [ISO]
- plasma membrane [IDA, ISO]
- postsynaptic density [IDA]
- protein complex [ISO]
Co-localization
Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments.
Publication
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.
In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Idax and Axin competed with each other for the binding to Dvl. Immunocytochemical analyses showed that Idax was localized to the same ... [more]
Throughput
- Low Throughput
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
AXIN1 DVL1 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
AXIN1 DVL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - |
Curated By
- BioGRID