BAIT

CTNNB1

Catnb
catenin (cadherin associated protein), beta 1
GO Process (159)
GO Function (26)
GO Component (40)

Gene Ontology Biological Process

Rattus norvegicus
PREY

CXXC4

Idax
CXXC finger protein 4
GO Process (2)
GO Function (2)
GO Component (3)
Rattus norvegicus

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A

In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Idax and Axin competed with each other for the binding to Dvl. Immunocytochemical analyses showed that Idax was localized to the same ... [more]

Mol. Cell. Biol. Jan. 01, 2001; 21(1);330-42 [Pubmed: 11113207]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: abnormal protein level (MP:0008469)

Additional Notes

  • Expression of Idax inhibits the activation of the Wnt signalling pathway as measured by a luciferase reporter gene

Curated By

  • BioGRID