DVL1
Gene Ontology Biological Process
- Wnt signaling pathway [ISO, TAS]
- Wnt signaling pathway, planar cell polarity pathway [ISO]
- axon extension [ISO]
- axon guidance [ISO]
- axonogenesis [ISO]
- canonical Wnt signaling pathway [IBA, ISO]
- cochlea morphogenesis [ISO]
- collateral sprouting [ISO]
- convergent extension involved in neural plate elongation [ISO]
- convergent extension involved in organogenesis [ISO]
- cytoplasmic microtubule organization [ISO]
- dendrite morphogenesis [ISO]
- negative regulation of protein binding [ISO]
- negative regulation of protein kinase activity [ISO]
- negative regulation of protein phosphorylation [ISO]
- neural tube development [ISO]
- neuromuscular junction development [ISO]
- neurotransmitter secretion [ISO]
- planar cell polarity pathway involved in neural tube closure [IBA, ISO]
- positive regulation of Wnt signaling pathway [ISO]
- positive regulation of canonical Wnt signaling pathway [ISO]
- positive regulation of neuron projection development [ISO]
- positive regulation of proteasomal ubiquitin-dependent protein catabolic process [ISO]
- positive regulation of protein phosphorylation [ISO]
- positive regulation of transcription, DNA-templated [ISO]
- prepulse inhibition [ISO]
- protein localization to microtubule [ISO]
- protein localization to nucleus [ISO]
- receptor clustering [ISO]
- regulation of neurotransmitter levels [ISO]
- regulation of protein phosphorylation [ISO]
- skeletal muscle acetylcholine-gated channel clustering [ISO]
- social behavior [ISO]
- synapse organization [ISO]
- transcription from RNA polymerase II promoter [ISO]
Gene Ontology Molecular Function
Gene Ontology Cellular Component
CXXC4
Gene Ontology Biological Process
Gene Ontology Molecular Function
Gene Ontology Cellular Component
Phenotypic Suppression
A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.
Publication
Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.
In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Idax and Axin competed with each other for the binding to Dvl. Immunocytochemical analyses showed that Idax was localized to the same ... [more]
Throughput
- Low Throughput
Ontology Terms
- phenotype: abnormal protein level (MP:0008469)
Additional Notes
- Expression of Idax inhibits the activation of the Wnt signalling pathway as measured by a luciferase reporter gene
Related interactions
Interaction | Experimental Evidence Code | Dataset | Throughput | Score | Curated By | Notes |
---|---|---|---|---|---|---|
DVL1 CXXC4 | Affinity Capture-Western Affinity Capture-Western An interaction is inferred when a bait protein is affinity captured from cell extracts by either polyclonal antibody or epitope tag and the associated interaction partner identified by Western blot with a specific polyclonal antibody or second epitope tag. This category is also used if an interacting protein is visualized directly by dye stain or radioactivity. Note that this differs from any co-purification experiment involving affinity capture in that the co-purification experiment involves at least one extra purification step to get rid of potential contaminating proteins. | Low | - | BioGRID | - | |
CXXC4 DVL1 | Co-localization Co-localization Interaction inferred from two proteins that co-localize in the cell by indirect immunofluorescence only when in addition, if one gene is deleted, the other protein becomes mis-localized. Also includes co-dependent association of proteins with promoter DNA in chromatin immunoprecipitation experiments. | Low | - | BioGRID | - | |
CXXC4 DVL1 | Reconstituted Complex Reconstituted Complex An interaction is detected between purified proteins in vitro. | Low | - | BioGRID | - | |
DVL1 CXXC4 | Two-hybrid Two-hybrid Bait protein expressed as a DNA binding domain (DBD) fusion and prey expressed as a transcriptional activation domain (TAD) fusion and interaction measured by reporter gene activation. | Low | - | BioGRID | - |
Curated By
- BioGRID