BAIT

DVL1

Xdsh, dsh1
dishevelled segment polarity protein 1
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis
PREY

CXXC4

Idax, Xldax, xIdax
CXXC finger protein 4
GO Process (0)
GO Function (0)
GO Component (0)
Xenopus laevis

Phenotypic Suppression

A genetic interaction is inferred when mutation or over expression of one gene results in suppression of any phenotype (other than lethality/growth defect) associated with mutation or over expression of another gene.

Publication

Inhibition of the Wnt signaling pathway by Idax, a novel Dvl-binding protein.

Hino S, Kishida S, Michiue T, Fukui A, Sakamoto I, Takada S, Asashima M, Kikuchi A

In attempting to clarify the roles of Dvl in the Wnt signaling pathway, we identified a novel protein which binds to the PDZ domain of Dvl and named it Idax (for inhibition of the Dvl and Axin complex). Idax and Axin competed with each other for the binding to Dvl. Immunocytochemical analyses showed that Idax was localized to the same ... [more]

Mol. Cell. Biol. Jan. 01, 2001; 21(1);330-42 [Pubmed: 11113207]

Throughput

  • Low Throughput

Ontology Terms

  • phenotype: abnormal dorsal-ventral axis patterning (MP:0001704)

Additional Notes

  • Co-injection of idax with Xwnt8 or dvl rescues secondary axis formation phenotpyes

Curated By

  • BioGRID